| 摘要: |
| 支气管哮喘是一种涉及Th1/Th2失衡的慢性气道过敏性疾病。Th2偏移是哮喘发病的主要原因之一。近年研究发现,T细胞免疫球蛋白和黏蛋白区域分子1(TIM-1)在调控哮喘发病过程中的T细胞活化及Th1/Th2分化中发挥重要作用,已成为当前研究热点之一。本文就TIM-1基因特点及其在支气管哮喘发病中的作用作一综述。 |
| 关键词: T细胞免疫球蛋白和黏蛋白区域分子1 T淋巴细胞 细胞分化 哮喘 |
| DOI：10.3724/SP.J.1008.2012.001135 |
| 投稿时间：2012-03-14修订日期：2012-05-10 |
| 基金项目:国家自然科学基金(30670912),上海市自然科学基金(11ZR1448600). |
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| TIM-1 and bronchial asthma |
| QIANG Li-xia1,2,JIN Shou-de2,SHI Zhao-quan1* |
(1. Department of Respiratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2. Department of Respiratory Medicine, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China
*Corresponding author.) |
| Abstract: |
| Bronchial asthma is a chronic airway allergy disease involving the imbalance of Th1/Th2. Th2 shift is one of the primary causes of asthma. Recent studies have found that T cell immunoglobulin and mucin domain molecule 1 (TIM-1) play important roles in T cell activation and Th1/Th2 differentiation in asthma, which has been intensively reported in recent researches. This article reviews the characteristics of TIM-1 gene and its role in the pathogenesis of bronchial asthma. |
| Key words: T cell immunoglobulin and mucin domain molecule 1 T-lymphocytes cell differentiation asthma |
