| 摘要: |
| miRNA作为一种重要的基因转录后水平负性调节因子,在少突胶质细胞分化发育及阿尔茨海默病发病机制中发挥重要的调控作用。而能形成髓鞘的少突胶质细胞在神经元动作电位的传导、突触可塑性及其在以认知缺陷为主要特征的阿尔茨海默病中有着重要作用。利用miRNA,尤其是少突胶质细胞特异性表达的miRNA来研究阿尔茨海默病的发病机制,必将为该病的药物研发和诊治提供新的思路。本文就miRNA、少突胶质细胞与阿尔茨海默病发病机制的相关研究进展进行简要综述。 |
| 关键词: 微RNAs 少突胶质细胞 阿尔茨海默病 发病机制 |
| DOI：10.3724/SP.J.1008.2012.00785 |
| 投稿时间：2012-02-07修订日期：2012-03-19 |
| 基金项目:国家自然科学基金(31071056). |
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| Research progress in miRNA, oligodendrocytes and Alzheimer’s disease |
| MAO Fang-yuan 1△, LI Jia-su 1△, CHEN Wan-yan1, YAO Zhong-xiang2* |
(1. Student Brigade, Third Military Medical University, Chongqing 400038, China;
2. Department of Physiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China
△Co-first authors.
*Corresponding author.) |
| Abstract: |
| miRNA, regarded as an important negative gene regulator at the post-transcriptional level, plays a critical role in oligodendrocyte differentiation and pathogenesis of Alzheimer’s disease. Myelinating oligodendrocytes are important for the conduction of action potentials, synaptic plasticity and also for cognitive deficits of Alzheimer’s disease. Application of miRNA, especially oligodendrocyte-specific miRNAs in studying the pathogenesis of Alzheimer’s disease, will provide a new insight for the drug development and clinical diagnosis of the disease. In this paper we review the research progress in miRNA, oligodendrocytes and Alzheimer’s disease. |
| Key words: microRNAs oligodendrocytes Alzheimer disease pathogenesis |
