ObjectiveTo investigate the safety and early efficacy of the cryosurgery ablation combined with transurethral resection of the prostate (TURP) for treatment of prostate cancer with middle leaf protruding into the bladder. MethodsTwo prostate cancer patients with middle leaf protruding into the bladder were treated by rectal ultrasound-guided argon-hilium percutaneous cryoablation combined with TURP. The prostate specific antigen (PSA) was examined and CT or MRI was performed two months after cryoablation. ResultsThe operation was successfully performed in both cases, with the operation time, rewarming time, and bleeding volumes being 115 min/110 min, 50 min/52 min, and 20 ml/15 ml, respectively. There was no hematuresis or Foley catheter blockage in the two cases, and the urinary catheters were successfully removed two weeks after operation, with no urine retention or urinary incontinence. Preoperative and postoperative (2 months later) pelvic CT or MRI scans showed that the prostatic volume was greatly reduced and the middle leaf protruding into the bladder disappeared. PSA levels were 0.909 ng/ml and 0.26 ng/ml two months after operation. ConclusionCryosurgery ablation of the prostate combined with TURP is safe and effective for treatment of prostate cancer with the middle leaf protruding into the bladder.