| 摘要: |
| 肝前体细胞(HPCs)是肝脏内具有自我更新、高度增殖和多向分化潜能的成体干细胞,不仅与肝脏再生修复密切相关,也与原发性肝癌发生、发展密切相关。本文简要总结了近几年有关肝前体细胞的生物学特性、来源、定位以及多种信号调控通路在其增殖、分化及形成肿瘤中的作用等研究进展。 |
| 关键词: 肝前体细胞 细胞分化 标志物 肝细胞癌 信号通路 |
| DOI：10.3724/SP.J.1008.2012.001129 |
| 投稿时间：2012-05-14修订日期：2012-09-26 |
| 基金项目: |
|
| Biological characteristics and regulatory mechanisms of hepatic progenitor cells: recent progress |
| WANG Ming-da,WANG Chao*,WU Meng-chao |
(Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438,China
*Corresponding author.) |
| Abstract: |
| Hepatic progenitor cells (HPCs) are adult stem cells with self-renewing, high proliferation and multi-directional differentiation abilities. HPCs are closely associated with liver regeneration and the development of hepatocellular carcinoma (HCC). This article reviews recent research progress in biological characteristics, source, location of HPCs and the roles of various HPCs signalings in the proliferation, differentiation and development of HCC. |
| Key words: hepatic progenitor cells cell differentiation biomarker hepatocellular carcinoma signaling pathway |
