LDL-C/HDL-C与冠状动脉病变程度的相关性研究
CSTR:
作者:
作者单位:

瑞金医院北院,瑞金医院北院,瑞金医院北院,瑞金医院北院

作者简介:

通讯作者:

中图分类号:

基金项目:


Relationship between LDL-C/HDL-C and severity of coronary artery disease
Author:
Affiliation:

ruijin hospital north,Rui Jin north Hospital,,ruijin north hospital

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的 探讨血脂与冠状动脉病变程度的相关性。方法 选择2005至2011年共4 751例经冠状动脉造影的住院患者,根据冠脉造影结果分为2组,冠脉狭窄≥50%为冠心病组(n=3 402),冠脉狭窄<50%为对照组(n=1 349)。冠心病组根据病变血管支数分为1支病变、2支病变、3支及3支以上病变3个亚组。测定患者的血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算LDL-C/HDL-C比值。比较上述指标在各组间的差异,并采用Spearman相关分析研究LDL-C/HDL-C比值与冠状动脉病变程度之间的关系,用多元逐步logistic回归分析确定冠心病的危险因素。结果 与对照组比较,冠心病组TG、TC、LDL-C水平及LDL-C/HDL-C比值升高,HDL-C水平降低,差异均有统计学意义(P<0.01);在冠心病组中,随着冠状动脉病变支数的增加,LDL-C/HDL-C比值逐渐升高(P<0.001),冠状动脉病变支数与LDL-C/HDL-C比值呈正相关(R=0.25,P<0.01);多元logistic回归分析显示高LDL-C/HDL-C比值为冠心病的独立危险因素。结论 LDL-C/HDL-C比值是冠心病的独立危险因素,且与冠状动脉病变程度呈正相关。

    Abstract:

    Objective To explore the relationship between blood lipids and the severity of coronary artery disease. Methods A total of 4 751 patients with chest pain were divided into two groups according to the results of coronary angiography: coronary artery disease group (n=3 402 stenosis in one main branch stenosis≥50%) and control group (stenosis<50%, n=1 349). According to the number of coronary artery stenosis, the coronary artery disease group was divided into three subgroups (group 1: 1 branch stenosis; group 2: 2 branch stenosis;and group 3: 3 or more than 3 branch stenosis).The serum total cholesterol (TC),triglycefides (TG),high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined and LDL-C/HDL-C was calculated.The relationship between lipids and the severity of coronary artery stenosis was analyzed by Spearman correlation analysis, and the risk factors of coronary artery disease were analyzed by multiple-stepwise logistic regression analysis. Results The levels of TG, TC, LDL-C and the ratio of LDL-C/HDL-C in the coronary artery disease group were significantly lower than those in the control group (P<0.01). LDL-C/HDL-C ratio increased with the increase of diseased branches in the disease group (P<0.001), and the number of diseased branches was positively correlated with the ratio of LDL-C/HDL-C (R=0.25, P<0.01). Logistic multiple regression analysis showed that high LDL-C/HDL-C level was an independent risk factor for coronary heart disease. Conclusion LDL-C/HDL-C ratio is an independent risk factor for coronary heart disease and it is positively correlated with the severity of coronary artery lesions.

    参考文献
    相似文献
    引证文献
相关视频

分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2013-10-12
  • 最后修改日期:2014-01-16
  • 录用日期:2014-02-19
  • 在线发布日期: 2014-03-25
  • 出版日期:
文章二维码
重要通知
友情提醒: 近日发现论文正式见刊或网络首发后,有人冒充我刊编辑部名义给作者发邮件,要求添加微信,此系诈骗行为!可致电编辑部核实:021-81870792。
            《海军军医大学学报》编辑部
关闭