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| 四种穿心莲二萜内酯类化合物的生物转化 |
| 王杰华1,王峥涛1,2,王莉莉1,王浙健1,马昭1,胡之璧1*,黎万奎1* |
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(1.上海中医药大学中药研究所,中药新资源与质量标准综合评价国家中医药管理局重点研究室,上海 201210
2.上海中医药大学中药研究所,中药标准化教育部重点实验室,上海 201210
*通信作者) |
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| 摘要: |
| 穿心莲二萜内酯类化合物是穿心莲的特征性成分,具有抗菌、抗病毒、抗炎、解热和抗癌等广泛的药理作用。本文主要从转化底物及转化涉及的反应类型、转化体系、转化产物的构效关系等三方面综述了4种穿心莲二萜内酯在生物转化方面的研究情况,并就目前存在的问题及前景展望进行简要陈述,以期为进一步研究穿心莲二萜内酯类化合物的生物转化提供参考。 |
| 关键词: 穿心莲二萜内酯类 生物转化 中药化学 |
| DOI： |
| 投稿时间：2013-02-22修订日期：2013-08-27 |
| 基金项目:“十二五”国家科技支撑计划课题 (2012BAI29B02). |
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| Biotransformation of 4 ent-labdane diterpenoid lactones of Andrographis paniculata:recent progress |
| WANG Jie-hua1,WANG Zheng-tao1,2,WANG Li-li1,WANG Zhe-jian1,MA Zhao1,HU Zhi-bi1*,LI Wan-kui1* |
(1. The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China
2. The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China
*Corresponding author.) |
| Abstract: |
| Ent-labdane diterpenoid lactones, the principal constituents of Andrographis paniculata, have a wide range of pharmacological effects, such as antibacterial, anti-viral, anti-inflammatory, antipyretic, and anti-cancer effect, etc. In this review the biotransformations of four principal ent-labdane diterpenoid lactones of A. paniculata are discussed from the following aspects: substrates and types of reaction, transformation systems, and structure activity relationships. Moreover, the currently-existing problems and the prospects are also described to provide reference for further studying the biotransformation of ent-labdane diterpenoid lactones of A. paniculata. |
| Key words: ent-labdane diterpenoid lactones of A. paniculata biotransformation pharmaceutical chemistry (TCD) |
