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| YKL-40和VEGF在尖锐湿疣组织中的表达及意义 |
| 刘强1,胡芳1,赵静1,牛理达1,张希琳1,于倩1,郑庆虎2*,吴建华1* |
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(1.第二军医大学长海医院皮肤科,上海 200433
2.解放军153中心医院皮肤科,郑州 450042
*通信作者) |
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| 摘要: |
| 目的 探讨人类软骨糖蛋白-39和血管内皮细胞生长因子在尖锐湿疣组织中的表达及意义。方法 采用免疫组化SP法检测33例尖锐湿疣组织和10例正常包皮组织中YKL-40和VEGF的表达。结果 尖锐湿疣组织中YKL-40和VEGF阳性强度多在()～(),正常对照组多在(-)～(+),两种蛋白表达阳性强度分别和正常对照组比较差异均有统计学意义(P<0.05),但两种蛋白表达的相关性(r=0.27,P>0.05)及在不同临床因素的表达差异无统计学意义(P>0.05)。 结论 尖锐湿疣组织中存在YKL-40和VEGF过表达,YKL-40和VEGF的过表达可能对尖锐湿疣的发生发展有一定作用。 |
| 关键词: YKL-40 血管内皮生长因子类 尖锐湿疣 细胞凋亡 |
| DOI：10.3724/SP.J.1008.2013.00639 |
| 投稿时间：2013-02-22修订日期：2013-03-08 |
| 基金项目: |
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| Expression and significance of YKL-40 and VEGF in condyloma acuminatum tissues |
| LIU Qiang1,HU Fang1,ZHAO Jing1,NIU Li-da1,ZHANG Xi-lin1,YU Qian1,ZHENG Qing-hu2*,WU Jian-hua1* |
(1. Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2. Department of Dermatology, No. 153 Hospital of PLA, Zhengzhou 450042, Henan, China
*Corresponding authors.) |
| Abstract: |
| Objective To explore the expression of YKL-40 and vascular endothelial cell growth factor (VEGF) in condyloma acuminatum (CA) tissues and the related significance. Methods The expressions of YKL-40 and VEGF were analyzed by immunocytochemical staining with streptavidin-peroxidase (SP) in 33 CA tissues and 10 foreskin tissues of normal person. Results The expression intensities of YKL-40 and VEGF varied largely from positive () to strongly positive () in CA tissues compared with negative (-) and positive (+) in normal foreskin tissues. The expressions of YKL-40 and VEGF proteins in CA tissues were significantly different from those in the normal human controls(P<0.05). No correlation was found between the expression of YKL-40 and VEGF proteins in CA tissues (r=0.27, P>0.05), and their expressions were not correlated with other clinical factors (P>0.05). Conclusion YKL-40 and VEGF are over-expressed in CA tissues, which may play a part in the occurrence and development of CA. |
| Key words: YKL-40 vascular endothelial growth factors condylomata acuminata apoptosis |
