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| 巨大房间隔缺损合并重度肺动脉高压患儿血浆偶联因子6含量升高 |
| 闫芳1,刘艳兵2,王军1*,张会军1,吕瑛1,董彦博1,李小兵1 |
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(1. 河北医科大学第一医院心脏外科, 石家庄 050031;
2. 石家庄市第三医院脊柱外科, 石家庄 050000
*通信作者) |
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| 摘要: |
| 目的 探讨偶联因子6（CF6）在先天性心脏病巨大房间隔缺损合并不同程度肺动脉高压中的变化。方法 收集2010年1月至2012年8月160例巨大房间隔缺损患儿资料，患儿4~16（9.7±2.1）个月，体质量3.5~8.3（6.9±2.1）kg。根据合并肺动脉高压情况将160例患儿分为3组：房间隔缺损未合并肺动脉高压组41例为对照组，房间隔缺损合并肺动脉高压但未达到重度肺动脉高压组76例为A组，房间隔缺损合并重度肺动脉高压组43例为B组。应用放射免疫分析法检测不同组别患儿血浆中CF6的含量，比较组间差异，并对CF6含量与肺动脉高压程度的相关性进行分析。结果 对照组、A组和B组CF6含量分别为（198.5±43.7）、（167.7±89.8）、（304.4±80.7）pg/mL，其中B组CF6含量较对照组和A组升高，差异有统计学意义（P<0.01），而对照组与A组之间差异无统计学意义（P>0.05）。重度肺动脉高压患儿肺动脉收缩压/血压收缩压比与血浆中CF6的含量呈正相关（r=0.781，P<0.01）。结论 巨大房间隔缺损合并重度肺动脉高压患儿血浆CF6含量升高，提示其可能是重度肺动脉高压形成的重要因素之一。 |
| 关键词: 房间隔缺损 偶联因子6 肺动脉高压 |
| DOI：10.3724/SP.J.1008.2014.00301 |
| 投稿时间：2013-07-14修订日期：2013-09-25 |
| 基金项目: |
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| Plasma coupling factor 6 is increased in children with large atrial septal defect and severe pulmonary hypertension |
| YAN Fang1,LIU Yan-bing2,WANG Jun1*,ZHANG Hui-jun1,LÜ Ying1,DONG Yan-bo1,LI Xiao-bing1 |
(1. Department of Cardiac Surgery, the First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei, China;
2. Department of Spinal Surgery, the Third Hospital of Shijiazhuang, Shijiazhuang 050000, Hebei, China
*Corresponding author.) |
| Abstract: |
| Objective To explore the changes of plasma coupling factor 6 (CF6) in children with large atrial septal defect and different degrees of pulmonary hypertension. Methods A total of 160 patients with large atrial septal defect and different degrees of pulmonary hypertension from January 2010 to August 2012 were retrospectively analyzed. The age of the patients ranged from 4 to 16 (mean 9.7±2.1) months old, and the weight ranged from 3.5 to 8.3 (mean 6.9±2.1) kg. The participants were divided into three groups: atrial septal defect without pulmonary artery hypertension (control group, n=41); atrial septal defect with pulmonary artery hypertension, but not to a severe degree (A group, n=76); and atrial septal defect with severe pulmonary artery hypertension (B group, n=43). The plasma CF6 levels were determined and compared by radioimmunoassay between different groups; the relation of CF6 levels with degree of pulmonary artery hypertension was analyzed. Results The plasma CF6 level was (198.5±43.7) pg/mL in the control group, (167.7±89.8) pg/mL in A group, and (304.4±80.7) pg/mL in B group, showing no significant difference between control group and A group (P>0.05), but with that in B group being significantly higher than those of control group and A group (P<0.01). We also found that the ratio of systolic pulmonary artery pressure to systolic blood pressure was positively correlated with plasma level of CF6 in atrial septal defect children with severe pulmonary artery hypertension (r=0.781, P<0.01). Conclusion The plasma CF6 level is obviously increased in children with large atrial septal defect and severe pulmonary artery hypertension. CF6 may be one of the reasons for severe pulmonary artery hypertension. |
| Key words: atrial heart septal defects coupling factor 6 pulmonary hypertension |
