Objective To investigate the differences of bone mineral density (BMD) among the patients with alcoholic or HBV-related liver cirrhosis, and healthy controls. Methods Dual-energy X-ray radiography was employed to determine the BMD of he lumbar vertebra and bilateral hip joints in 57 patients with alcoholic cirrhosis, 67 with hepatitis B cirrhosis, and 175 healthy controls. The demographic data and clinical characteristics(hepatic fibrosis and hepatic function) of all the participants were collected. Independent sample t-test was used to compare the differences among 3 groups and multiple classified logistical regression analysis was used to evaluate factors influencing BMD. Results The BMD of alcoholic cirrhosis and HBV-related cirrhosis patients were significantly lower than that of healthy controls(P<0.01), and the BMD in alcohol cirrhosis patients was significantly lower than that in HBV-related cirrhosis patients(P<0.05). Univariate logistic regression analysis identified that female gender, elder age, liver cirrhosis degree, and liver function were significantly correlated with the levels of BMD(P<0.01). Multivariate analysis showed that alcoholic cirrhosis (OR=2.053, 95%CI=1.931-3.852) and HBV-related cirrhosis (OR=1.521, 95%CI=1.342-2.354) were the independent risks of reduced BMD in patients. Conclusion BMD levels of patients with alcoholic cirrhosis and HBV-related cirrhosis are significantly lower than that of the healthy controls, and hepatic cirrhosis is independent factor of osteoporosis.