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| 中国2004—2010艾滋病母婴传播率及母婴阻断药物应用状况的系统评价 |
| 代容1,冯婧1,唐茂芝2,刘喜2,钟艺2,赵勇1,LeiZhang3,EricP.F.Chow3,4,5,汪洋1,曾缓1* |
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(1. 重庆医科大学公共卫生与管理学院, 重庆 400016;
2. 重庆医科大学儿科学院, 重庆 400016;
3. The Kirby Institute, University of New South Wales, Sydney, New South Wales, NSW 2010, Australia;
4. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Vic 3053, Australia;
5. Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Victoria, Vic 3053, Australia
*通信作者) |
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| 摘要: |
| 目的 了解我国2004—2010年艾滋病母婴传播及母婴阻断药物应用状况。方法 全面检索中国生物医学文献数据库(CBM)和PubMed等中英文数据库中中国艾滋病母婴传播相关文献,检索时间均从建库到2013年5月。对纳入的文献采用参照AHRQ横断面研究评价标准和STROBE声明拟定的4条标准进行质量评价。将样本量、监测地点和监测年份作为主要异质性来源进行meta回归分析。采用Comprehensive Meta-Analysis V2.0 software 进行meta分析。结果 共检索到2 356篇文献,最终纳入51篇进行分析。2004—2010年我国艾滋病母婴传播率依次分别为12.90%(95% CI: 7.48%~21.36%)、16.35%(95% CI: 10.41%~24.73%)、6.45%(95% CI: 3.73%~10.93%)、6.25%(95% CI: 2.39%~15.36%)、5.56%(95% CI: 2.79 %~10.76%)、3.10%(95% CI: 1.59 %~5.97%)、2.29%(95% CI: 1.36 %~3.83%),孕产妇中阻断药物应用率依次分别为70.39%(95% CI: 24.42%~94.59%)、71.99%(95% CI: 61.49%~80.54%)、78.79%(95% CI: 70.19%~85.43%)、86.84%(95% CI: 79.24%~91.94%)、82.71%(95% CI: 76.62%~87.48%)、81.85%(95% CI: 75.55%~86.80%)、86.16%(95% CI: 53.20%~97.15%)；2005—2010年婴儿阻断药物应用率依次分别为80.72%(95%CI: 72.89%~86.70%)、81.84%(95% CI:71.55%~88.98%)、85.43%(95% CI:80.99%~88.97%)、89.75%(95% CI: 81.82%~94.45%)、92.39%(95% CI: 84.97%~96.31%)、90.34%(95% CI: 85.50%~93.68%)。结论 近年来我国艾滋病母婴传播率呈下降趋势,孕产妇及婴儿阻断药物应用率都有所升高。 |
| 关键词: 人类免疫缺陷病毒 艾滋病 母婴传播 系统评价 meta分析 |
| DOI：10.3724/SP.J.1008.2014.01094 |
| 投稿时间：2014-02-28修订日期：2014-09-09 |
| 基金项目:中国循证卫生保健协作网项目(x7254)，澳大利亚政府Endeavour奖学金 (ERF_PDR_3100_2012). |
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| Mother-to-child transmission rate of HIV and use of drugs to prevent the transmission in China: a systematic review |
| DAI Rong1,FENG Jing1,TANG Mao-zhi2,LIU Xi2,ZHONG Yi2,ZHAO Yong1,Lei Zhang3,Eric P. F. Chow3,4,5,WANG Yang1,ZENG Huan1* |
(1. School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China;
2. School of Pediatric Medicine, Chongqing Medical University, Chongqing 400016, China;
3. The Kirby Institute, University of New South Wales, Sydney, New South Wales, NSW 2010, Australia;
4. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Vic 3053, Australia;
5. Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Victoria, Vic 3053, Australia
*Corresponding authors) |
| Abstract: |
| Objective To understand the mother-to-child transmission rate of human immunodeficiency virus (HIV) and the use of drugs to prevent the transmission in China from 2004 to 2010. Methods English and Chinese databases including PubMed, Chinese Biomedical Literature database (CBM), etc. were searched to retrieve the relevant references from the start to May 2013. Quality evaluation of the included studies was performed with four criteria which was compiled according to AHRQ cross-sectional study evaluation standards and the STROBE statement. The sample size, recruitment venue and study year were taken as the main source of heterogeneity in meta regression analysis. The data was analyzed by Comprehensive Meta-Analysis V2.0 software. Results A total of 2 356 references were retrieved, and 51 of them were finally included in meta-analysis. In 2004-2010, the mother-to-child transmission rates of HIV were 12.90%(95% CI: 7.48%-21.36%),16.35%(95% CI: 10.41%-24.73%),6.45%(95% CI: 3.73%-10.93%),6.25%(95% CI: 2.39%-15.36%),5.56%(95% CI: 2.79%-10.76%),3.10%(95% CI: 1.59%-5.97%), and 2.29%(95% CI: 1.36%-3.83%), respectively. Meanwhile, From 2004 to 2010, the drug use rates for HIV antiretroviral prophylaxis among pregnant women were 70.39%(95% CI: 24.42%-94.59%),71.99%(95% CI: 61.49%-80.54%),78.79%(95% CI: 70.19%-85.43%), 86.84%(95% CI: 79.24%-91.94%), 82.71%(95% CI: 76.62%-87.48%), 81.85%(95% CI: 75.55%-86.80%), and 86.16%(95% CI: 53.20%-97.15%), respectively. And in 2005-2010, the drug use rates for HIV antiretroviral prophylaxis among infants were 80.72%(95%CI: 72.89%-86.70%), 81.84%(95% CI:71.55%-88.98%), 85.43%(95% CI: 80.99%-88.97%), 89.75%(95% CI: 81.82%-94.45%), 92.39%(95% CI: 84.97%-96.31%), and 90.34%(95% CI: 85.50%-93.68%), respectively. Conclusion The HIV mother-to-child transmission rate is decreasing in China in recent years, and the drug use rates of HIV antiretroviral prophylaxis are increasing among HIV-infected pregnant women and their infants. |
| Key words: human immunodeficiency virus acquired immune deficiency syndrome mother-to-child transmission systematic review meta-analysis |
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