| 摘要: |
| Irisin是一种新发现的肌源性糖基化多肽,能促使白色脂肪细胞解偶联蛋白表达,诱导脂肪小滴形成,增加线粒体密度,增加脂肪细胞氧耗,导致白色脂肪细胞棕色样变,促进β细胞再生,从而抑制肥胖和胰岛素抵抗的发生;Irisin还能增加脑源性神经营养因子,激活参与学习和记忆的基因,从而改善认知;还能延长端粒从而延缓衰老等。本文综述了Irisin与老年2型糖尿病的关系,以期为老年2型糖尿病的有效防治提供参考。 |
| 关键词: 老年人鸢尾素 2型糖尿病 Ⅲ型纤维蛋白域包含蛋白5 米色脂肪 脑源性神经营养因子 端粒 |
| DOI：10.16781/j.0258-879x.2016.01.0072 |
| 投稿时间：2015-04-21修订日期：2015-08-13 |
| 基金项目: |
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| Irisin and type 2 diabetes mellitus in the elderly |
| HUANG Xiang-qin1,CAO Xian2,HUANG Qin1* |
(1. Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. The Xiang'an Cadre Santatorium, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Irisin is a newly discovered myogenic glycosylation of peptide which can promote expression of uncoupling protein in white fat cells, facilitate lipid droplet formation, increase mitochondrial density and oxygen consumption of fat cells, and results in the shift from white fat cells to brown fat cells and promotion of β cells regeneration, thus inhibiting the occurrence of obesity and insulin resistance. Meanwhile, Irisin can also increase brain-derived neurotrophic factor, activate genes involved in learning and memorizing, so as to improve cognition function. Furthermore, Irisin is also reported to mitigate aging by extending the length of telomeres. This paper reviewed the relationship between Irisin and type 2 diabetes in the elderly, hoping to provide reference for prevention and treatment of type 2 diabetes in the elderly. |
| Key words: irisin aged type 2 diabetes mellitus fibronectin type Ⅲ domain containing protein 5 beige fat brain-derived neurotrophic factor telomere |
