| 摘要: |
| 妊娠期间胎盘高表达过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptors, PPARs),但其生理作用尚不明确。本文从PPARs结构特点、作用机制、在人胎盘中的分布和功能,以及与病理性妊娠可能关系等方面进行综述,以揭示PPARs在人胎盘胎儿发育、妊娠维持和分娩启动等过程中起重要作用。 |
| 关键词: 过氧化物酶体增殖物激活受体 胎盘 胎儿发育 妊娠 分娩 |
| DOI：10.3724/SP.J.1008.2015.00983 |
| 投稿时间：2015-01-11修订日期：2015-07-11 |
| 基金项目:国家自然科学基金面上项目(31371175). |
|
| Peroxisome proliferator activated receptors in human placenta: expression and function |
| HE Ping1,WANG Yi-lin2,NI Xin1* |
(1. Department of Physiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China;
2. The 7th Team of Graduate Student Administration Brigade, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Although it has been demonstrated that peroxisome proliferator activated receptors (PPARs) are abound in human placenta during pregnancy, the physiological function of PPARs is still not clear. This review focused on the PPARs structural features, action mechanism, distribution and function in the human placenta, and the possible relationship with pathological pregnancy, so as to reveal the role of PPARs in placenta and fetal development, pregnancy-maintenance and the start of labor. |
| Key words: peroxisome proliferator-activated receptors placenta fetal development pregnancy parturition |
