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| 上海市60岁以上人群代谢综合征与骨密度的相关性 |
| 李静怡1,2,葛军2,孟健2,顾庆2,俞春芳2,刘志民1* |
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(1. 第二军医大学长征医院内分泌科, 上海 200003;
2. 上海市市东医院内分泌科, 上海 200438
*通信作者) |
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| 摘要: |
| 目的 探讨老年人群代谢综合征（MS）与骨密度(BMD)的相关性。方法 将1002例老年人根据有无MS分为MS组、非MS（NMS）组，测量身高、体重、腰围、血压，计算体重指数（BMI），检测血总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）。使用定量超声骨密度仪测量跟骨BMD。采用协方差分析比较MS与非MS研究对象间BMD差异，并分析BMD相关危险因素。结果 与NMS组相比，MS组BMI、腰围、TC、TG、FPG均高于NMS组，差异有统计学意义（P<0.05或P<0.01）。剔除年龄、BMI后，MS组BMD高于NMS组（P<0.01）。MS各亚组间未剔除影响因素前，3组BMD无差异（P>0.05）,逐步剔除年龄、BMI后，3组BMD差异有统计学意义（P<0.05）。多元逐步回归分析显示年龄、腰围、HDL-C是影响BMD的独立相关因素（P<0.05）。结论 合并MS的老年人群BMD较非MS者增加。 |
| 关键词: 老年人 代谢综合征 骨密度 |
| DOI：10.3724/SP.J.1008.2015.00922 |
| 投稿时间：2015-01-14修订日期：2015-04-14 |
| 基金项目: |
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| Relationship between metabolic syndrome and bone mineral density in the elderly aged over 60 years in Shanghai |
| LI Jing-yi1,2,GE Jun2,MENG Jian2,GU Qing2,YU Chun-fang2,LIU Zhi-min1* |
(1. Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
2. Department of Endocrinology, Shanghai Shidong Hospital, Shanghai 200438, China
*Corresponding author) |
| Abstract: |
| Objective To investigate the relationship between metabolic syndrome (MS) and bone mineral density(BMD) in the aged. Methods 1002 cases were divided into MS group and non-MS(NMS)group according to with or without MS. Height, weight, waist circumference and blood pressure were measured, body mass index(BMI) were calculated, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) ,fasting blood glucose (FBG)were tested. The calcaneal bone mineral density (BMD) was measured by the quantitative ultrasonography. To find the differences of BMD between subjects with or without MS by using the covariance analysis and to analyze the risk factors associated with BMD. Results Compared to NMS group, the values of BMI、waist circumference、TC、TG、FPG were significantly increased in MS group(P<0.05或P<0.01).Those with MS had higher BMD than those without after adjustment for age and BMI（P<0.01）. There was no significant difference in BMD among patients with different number of the components of the metabolic syndrome (P<0.05). However，the difference were significant after adjustment for age and BMI（P<0.05）.The multiple stepwise regression analysis demonstrated that BMD were correlated with age、waist circumference and HDL-C（P<0.05）.Conclusion .The BMD is higher in aged MS patients than that in non-MS subjects. |
| Key words: aged metabolic syndrome bone density |
