| 摘要: |
| 埃博拉病毒是迄今发现的最凶险、对人类生命危害最大的病毒之一,能在人类和非人灵长类动物中引起严重的埃博拉出血热,病死率可高达90%,并且目前还没有有效的疫苗和治疗药物。面对埃博拉病毒带来的挑战,针对该病毒的实验室诊断、治疗药物以及疫苗的研究已经成为病毒学领域的热点。本文就埃博拉病毒的起源与流行、分子生物学特性、致病机制、病原检测及疫苗研究的新进展作一综述。 |
| 关键词: 埃博拉病毒 流行病学 致病机制 诊断 疫苗 |
| DOI：10.3724/SP.J.1008.2015.00188 |
| 投稿时间：2014-08-23修订日期：2015-01-07 |
| 基金项目: |
|
| Research progress on Ebola virus |
| XU Qing-qiang△,TANG Hai-lin△,QI Zhong-tian* |
(Department of Biological Prevention (Microbiology), Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai Key Laboratory of Medical Biodefense, Shanghai 200433, China
△Co-first author.
*
|
| Abstract: |
| Ebola virus is a highly virulent pathogen which can cause severe viral hemorrhagic fever in humans and non-human primates, with the case fatality rates being as high as 90%. Currently, there is neither a specific treatment nor a vaccine licensed for use in humans. The challenge brought by the Ebola epidemic has promoted the following research focuses: specific and sensitive detection techniques, safe and effective vaccines and drugs. Here, we summarized the epidemiology, biology and pathogenesis of ebola virus, as well as the recent advances in diagnosis and vaccines for prevention of Ebola hemorrhagic fever. |
| Key words: Ebola virus epidemiology pathogenesis diagnosis vaccines |
