| 摘要: |
| 肝细胞癌是我国最常见的一种原发性肝癌,目前发病原因尚不明确。研究表明,多种细胞信号转导通路的异常活化参与肝癌的发生发展,包括:血管内皮细胞生长因子受体、表皮生长因子受体、血小板衍生生长因子受体、类胰岛素生长因子受体等,这些信号通路的异常活化最终导致细胞增殖、血管形成、侵袭和转移及对凋亡耐受的发生。目前肝癌的治疗方法主要包括药物、手术、放射治疗及生物免疫治疗等,但这些传统治疗方法对肝癌治愈效果不佳,副作用大,随着对肝癌相关信号通路的研究逐步深入,以上述通路为靶点的抗肿瘤治疗为肝癌治疗提供了新的前景。 |
| 关键词: 肝肿瘤 肝细胞癌 信号通路 治疗靶标 表皮生长因子受体 乙型肝炎病毒 |
| DOI：10.3724/SP.J.1008.2015.00373 |
| 投稿时间：2014-09-26修订日期：2014-12-31 |
| 基金项目:国家重点基础研究项目("973"计划,2015CB554000). |
|
| Hepatocellular carcinoma: progress in signaling pathways and therapeutic targets |
| WU Jian-feng1,ZHAO Teng2,CAO Guang-wen1* |
(1. Department of Epidemiology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China;
2. The 5th Team of Student Brigade, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Hepatocellular carcinoma is the most commonly-seen primary liver cancer in China, with its etiology still not fully understood. Research has shown that many signaling pathways are involved in the development and progression of liver cancer, including vascular endothelial growth factor receptor, epidermal growth factor receptor, platelet-derived growth factor receptor, insulin-like growth factors receptor, and so on. The abnormality of these signaling pathways finally leads to cell proliferation, angiogenesis, invasion and metastasis, and apoptosis tolerance. The current treatment of liver cancer mainly includes drugs, surgery, radiation therapy and immune therapy, but there is still an urgent needs for more effective treatment with less adverse effect. It is hoped that with the progression in the signal pathways of hepatic cancer, anti-tumor treatments with these signal pathways as the targets will cast new lights for liver cancer treatment. |
| Key words: liver neoplasms hepatocellular carcinoma signaling pathway therapeutic target endothelial growth factor receptor hepatitis B virus |
