中老年人群中血清HER-2水平与代谢综合征的关系
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上海交通大学医学院附属新华医院崇明分院 上海交通大学医学院附属新华医院

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Association of serum HER-2 level with metabolic syndrome in middle-aged and elderly population
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Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, Shanghai, China

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    摘要:

    目的 探讨中老年人群血清HER-2水平与代谢综合征的关联性。方法 研究人群为崇明城桥社区687名中老年人群, 其中男性309例, 女性378例。血清HER-2水平采用ELISA方法检测。代谢综合征定义依据NCEP ATPⅢ(National Cholesterol Education Program Adult Treatment Panel Ⅲ, NECP ATPⅢ)亚裔美国人标准。结果 在校正相关影响因素后, 代谢综合征(+)组(n=370)血清HER-2水平高于对照组(n=317)[(12.4±2.3) ng/mL vs (8.2±1.6) ng/mL, P<0.001]。随着代谢综合征组分累加, 血清HER-2水平增加(P<0.001)。校正其他风险因素后, 多元logistic回归分析显示第4四分位数血清HER-2值组其代谢综合征发生风险较第1四分位数组增加, 其OR值为1.35(95% CI: 1.14~2.31, P<0.001)。结论 在中老年人群中血清HER-2水平与代谢综合征发病风险相关, 且这种关联性独立于其他代谢综合征的风险因素。

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    Objective To investigate the association of circulating HER-2 level with metabolic syndrome in middle-aged and elderly population. Methods We conducted a population-based cross-sectional study with 687 participants aged 40 years or older from a community in Chongming District, Shanghai, China. Serum HER-2 levels were measured using ELISA. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel Ⅲ (NCEP ATP Ⅲ) criteria for Asian-Americans. Results After adjusting for other influencing factors, we found that the participants with metabolic syndrome (n=370) had significantly higher HER-2 level compared with the control group (n=317) ([12.4±2.3] ng/mL vs [8.2±1.6] ng/mL, P<0.001). The serum HER-2 level increased (P<0.001) with the accumulation of the metabolic syndrome components. After adjusting for potential risk factors, multiple logistic regression analysis showed that the highest quartile of serum HER-2 was associated with increased risk of metabolic syndrome, with a fully adjusted odds ratio (OR) of 1.35 (95% confidence interval [CI]: 1.14-2.31), P<0.001). Conclusion Serum HER-2 is independently associated with metabolic syndrome in middle-aged and elderly Chinese in this study.

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  • 收稿日期:2014-11-06
  • 最后修改日期:2015-02-06
  • 录用日期:2015-04-15
  • 在线发布日期: 2015-05-19
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