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| 群体药代动力学用于丙戊酸钠个体化给药 |
| 游春华1,2,恽芸蕾1,高守红1*,张凤1,陈万生1,熊筱娟2 |
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(1. 第二军医大学长征医院药材科, 上海 200003;
2. 宜春学院江西省天然药物活性成分研究重点实验室, 宜春 336000
*通信作者) |
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| 摘要: |
| 丙戊酸钠是目前临床上最常用的广谱抗癫疒 间 药物。其治疗窗窄,体内代谢受多种因素的影响,不同个体间差异较大,临床需对其进行个体化给药。群体药代动力学是近年来发展迅速的一种药代动力学的群体分析方法。本文对近年来丙戊酸钠体内代谢过程和群体药代动力学研究及应用作一综述,分析归纳影响丙戊酸钠代谢的可能因素,如人口学特征、合并用药及遗传因素等,从而为临床个体化给药提供参考。 |
| 关键词: 丙戊酸钠 群体药代动力学 个体化给药 |
| DOI：10.3724/SP.J.1008.2015.01329 |
| 投稿时间：2015-03-19修订日期：2015-06-03 |
| 基金项目:国家自然科学基金(81302856),上海市科学技术委员会计划项目(13ZR1413800). |
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| Population pharmacokinetics in individualized drug dosage regimes of valproate |
| YOU Chun-hua1,2,YUN Yun-lei1,GAO Shou-hong1*,ZHANG Feng1,CHEN Wan-sheng1,XIONG Xiao-juan2 |
(1. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
2. Key Laboratory of Natural Active Pharmaceutical Constituents of Jiangxi Province, Yichun University, Yichun 336000, Jiangxi, China
*Corresponding author.) |
| Abstract: |
| Valproate is commonly used as a first-line broad-spectrum anti-epileptic drug. Valproate has a narrow therapeutic window, its metabolism is affected by many factors, and it has great individual differences, which makes individualized drug dosage regime needed for valproate. Population pharmacokinetics is a population analytical method developed in recent years. This paper reviewed the in vivo metabolic process and the population pharmacokinetics of valproate in recent years, and analyzed the factors that may affect the metabolism of valproate, including demographic factors, genetic factors and concomitant medications, hoping to provide reference for clinical individualized drug dosage regime. |
| Key words: valproate population pharmacokinetics individual treatment |
