Ebola virus disease (EVD) caused by Ebora virus (EBOV) is one of the most violent infectious disease so far. It is so highly infective and fatal that there has been no effective treatment until now. Ebola viral infection can cause a series of immune responses. Specific and nonspecific antiviral innate immune deficiency in the hosts is a recognized important reason for EVD associated death. This paper reviews the influence of EBOV on innate immune reaction of humans and the corresponding countermeasures.