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| 血管及遗传因素对阿尔茨海默病发生、发展的影响 |
| 车皓月1,王闰2,单磊3,潘勇华1,高申1,王忠壮1,傅芃1* |
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(1. 第二军医大学长海医院药学部, 上海 200433;
2. 解放军85医院药材科, 上海 200050;
3. 第二军医大学药学院药学队, 上海 200433
*通信作者) |
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| 摘要: |
| 阿尔茨海默病（Alzheimer disease，AD）是一种中枢神经退行性疾病，病因复杂。近年来研究发现，血管病变对AD有较大影响，血管内皮生长因子（vascular endothelial growth factor，VEGF）表达异常在患者病程中承担重要角色；同时AD患者脑内部分miRNA表达水平有明显变化。本文综述了血管病变及遗传因素对AD发生、发展的影响，并对可能的发病机制、相关治疗靶点及策略进行讨论与展望。 |
| 关键词: 阿尔茨海默病 神经退行性疾病 血管内皮生长因子类 微RNAs |
| DOI：10.16781/j.0258-879x.2016.10.1261 |
| 投稿时间：2016-01-22修订日期：2016-03-15 |
| 基金项目:国家自然科学基金（81402819，81373327），上海市自然科学基金（13ZR1408500），总后勤部卫生部基金面上项目（14ZJ202-3）. |
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| Role of vascular and genetic factors in Alzheimer disease |
| CHE Hao-yue1,WANG Run2,SHAN Lei3,PAN Yong-hua1,GAO Shen1,WANG Zhong-zhuang1,FU Peng1* |
(1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. Department of Medicine, No. 85 Hospital of PLA, Shanghai 200050, China;
3. The Pharmacy Student Team, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Alzheimer disease (AD) is a neurodegenerative disease of the central nervous system, with complicated etiologies. Recent studies have found that vascular disease has a great impact on AD, and abnormal vascular endothelial growth factor (VEGF) expression is thought to play an important role in the course of AD. MicroRNAs expression has greatly changed in the brain of AD patients. This paper reviewed the latest advance in the effects of vascular and genetic factors on the occurrence and progression of AD, with discussion also on the probable pathogenesis, therapeutic targets and strategies of AD. |
| Key words: Alzheimer disease neurodegenerative diseases vascular endothelial growth factors microRNAs |
