| 摘要: |
| Survivin是凋亡抑制蛋白(inhibitor of apoptosis protein, IAP)家族的新成员, 参与调控细胞重要的生理病理过程, 具有抑制细胞凋亡、促进细胞增殖和肿瘤间质血管形成等作用。Survivin在正常终末分化组织中几乎检测不到, 而在大多数肿瘤组织中高表达, 其异常高表达与肿瘤的化疗耐药、肿瘤复发以及患者生存率密切相关。由于在肿瘤发生和发展中起重要作用, Survivin成为肿瘤基因诊治的理想靶点。本文将就Survivin分子功能、Survivin与肿瘤的关系以及与Survivin相关的肿瘤治疗策略作一综述。 |
| 关键词: survivin 启动子 肿瘤 细胞凋亡 自噬 靶向治疗 |
| DOI：10.16781/j.0258-879x.2016.03.0342 |
| 投稿时间：2015-10-21修订日期：2015-12-15 |
| 基金项目: |
|
| Survivin-targeted tumor treatment strategy |
| YIN Hai-sen1,ZHAO Xin-ying2,SU Chang-qing1,2* |
(1. The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, China;
2. Department of Molecular Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
*Corresponding author) |
| Abstract: |
| Survivin, a new member of inhibitors of apoptosis proteins(IAP) family, regulates the essential cellular processes, including inhibition of cell apoptosis, promotion of cell proliferation and tumor stromal angiogenesis. Survivin is undetectable in most terminally differentiated tissues, but upregulated in almost all types of human malignancies and its aberrant overexpression positively correlates with chemotherapy resistance, increased tumor recurrence and shortened patient survival. Because of its key role in tumor formation and development, Survivin is considered as an ideal target for anticancer treatment. This review discussed the molecular function of Survivin, relationship between Survivin and cancer biological characteristics, as well as the research progress of cancer therapy targeting Survivin. |
| Key words: survivin promoter neplasms apoptosis autophagy targeted therapy |
