| 摘要: |
| 病理性疼痛是指由创伤、感染、肿瘤等因素造成组织病理性改变后引起的疼痛。疼痛若持续1个月以上或在损伤组织愈合后持续存在则演变为慢性疼痛。慢性疼痛患者常伴有失眠、焦虑、抑郁等精神心理疾病,正常的生理功能和生活质量严重受损,带来许多社会经济问题。最新研究发现,表观遗传学调控可以在分子水平解释各种慢性病理性疼痛,包括炎性疼痛、神经病理性疼痛和精神源性疼痛的发病机制,进而引领其治疗手段的发展。本文围绕表观遗传学中DNA甲基化、组蛋白乙酰化和小干扰RNA(miRNA)调控这3种主要机制在慢性病理性疼痛领域的最新研究进展作一综述。 |
| 关键词: 病理性疼痛 表观遗传学 DNA甲基化 组蛋白乙酰化 miRNA |
| DOI：10.16781/j.0258-879x.2016.02.0208 |
| 投稿时间：2015-09-25修订日期：2015-12-21 |
| 基金项目: |
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| Epigenetic mechanisms of chronic pathological pain: research progress |
| LI Wen-qian,YU Wei-feng* |
(Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
*Corresponding author) |
| Abstract: |
| Pathological pain refers to the pain that caused by the tissue injury due to trauma, infection, tumor, etc. It may turn into chronic pain if it lasts for more than one month or remains when the tissue injury is healed. Patients with chronic pain often suffer insomnia, anxiety, depression and other mental disorders, which may seriously impair their physical function and quality of life, subsequently leading to many social and economic problems. Recent studies have found that epigenetic regulation may explain, at molecular level, the pathogenesis of pathological pain, including inflammation pain, neuropathic pain and psychological pain, which may lead to the development of its therapeutic means. In this article, we reviewed the latest research progress of epigenetic regulation of chronic pathological pain, including DNA methylation, histone acetylation and miRNA activity. |
| Key words: pathological pain epigenetics DNA methylation histone acetylation miRNA |
