| 摘要: |
| 肾脏血管系统对于正常肾功能的维持非常重要，血管内皮生长因子A（vascular endothelial growth factor-A，VEGF-A）与肾脏血管系统的发育和多种肾脏疾病密切相关。研究表明，肾组织中VEGF-A表达下调可引起肾髓质微血管密度降低，造成肾组织局部缺氧，反馈性导致促红细胞生成素增多，造成红细胞增多症；而VEGF-A过表达则可导致肾脏纤维化、肾囊肿形成，促进肾脏疾病进展。因此，调控VEGF-A的表达可能影响肾脏疾病的发生与发展。本文对VEGF-A在肾脏血管系统发育和肾脏疾病中的作用进行综述，为肾脏疾病提供新的治疗策略。 |
| 关键词: 血管内皮生长因子A 肾脏血管系统 肾疾病 |
| DOI：10.16781/j.0258-879x.2016.07.0863 |
| 投稿时间：2015-11-25修订日期：2016-02-12 |
| 基金项目:国家科技支撑计划项目（2013BAI09B04）. |
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| Role of vascular endothelial growth factor-A in kidney development and kidney diseases |
| ZHOU Jie,YANG Yang,SONG Shu-wei,MEI Chang-lin* |
(Department of Nephrology, Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
* Corresponding author) |
| Abstract: |
| The renal vascular system is vital for maintaining the normal function of kidney, and vascular endothelial growth factor-A (VEGF-A) participates in the development of renal vascular system and is associated with various kidney diseases.Studies have demonstrated that down-expression of renal VEGF-A can result in reduction of microvascular density in medulla kidney, regional hypoxia, and polycythemia, and further lead to increased haemopoietin. The overexpression of VEGF-A can cause renal fibrosis and cyst formation, promoting the progress of kidney disease. Therefore, regulation of VEGF-A expression may influence the occurrence and development of kidney diseases. This review summarized the role of VEGF-A in the renal vascular system and kidney diseases, hoping to provide new therapeutic strategies for kidney diseases. |
| Key words: vascular endothelial growth factor-A renal vascular system kidney diseases |
