| 摘要: |
| 目的 探讨持续低频噪声对大鼠情绪及行为的影响。方法 将40只大鼠采用随机数字法分为正常对照组及噪声暴露组,每组20只。将噪声暴露组大鼠每天早、中、晚3次置于100 Hz、70 dB的噪声场中1 h,持续8周;正常对照组大鼠饲养于背景噪声低于40 dB的环境中。分别于实验开始当天及第2、4、6、8周末,采用体质量测定、糖水偏好实验、触动实验及旷场实验评价大鼠的情绪及行为。结果 (1)随饲养时间的延长两组大鼠体质量变化的趋势不同(P<0.05),噪声暴露组大鼠的体质量增加较正常对照组减少;(2)不考虑时间因素,两组大鼠间糖水偏好的主效应差异有统计学意义(P<0.01);噪声暴露组大鼠与正常对照组大鼠随饲养时间的延长糖水偏好的变化趋势不同(P<0.01),其中噪声暴露组大鼠的糖水偏好百分比呈明显下降趋势;(3)噪声暴露组大鼠紧张性触动评分及疼痛刺激评分均高于正常对照组,差异有统计学意义(P<0.05或P<0.01);(4)噪声暴露组大鼠的水平活动能力和垂直活动能力随暴露时间的延长呈下降趋势,且低于正常对照组,时间效应、组别效应及交互效应均有统计学意义(P<0.05或P<0.01)。结论 持续低频噪声可导致大鼠体质量和活动能力下降,并出现焦虑、抑郁等情绪反应,且具体的表现及程度与暴露时间有关。 |
| 关键词: 噪声 低频 持续 情绪 行为 |
| DOI：10.16781/j.0258-879x.2016.06.0718 |
| 投稿时间：2015-10-28修订日期：2016-01-26 |
| 基金项目:山东省淄博市科技局科技发展项目(2014KJ010003). |
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| Effects of continuous low frequency noise on the emotion and behavior of rats |
| ZONG Li1,ZHANG Zheng-hua1*,XIE Dan1,KANG Jing1,XU Miao-miao1,LI Zi-qiang2 |
(1. The Third Department of Occupational Disease, Zibo Prevention and Treatment Hospital for Occupational Diseases, Zibo 255022, Shandong, China;
2. Department of Medical Psychology, Faculty of Mental Health and Psychology, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Objective To explore the effects of continuous low frequency noise on the emotion and behavior of rats. Methods Forty rats were randomly divided into normal control (NC) group and noise exposure(NE) group, with 20 rats in each group. Rats in NE group were exposed to 100 Hz, 70 dB noise for 1 hour at early, middle and late time of the day in a daily manner for 8 weeks. Rats in NC group were raised in normal background noise in an environment with a noise less than 40 dB. The body mass measurement, sucrose preference test, handling test and open field test were done to evaluate the emotion and behavior of rats at the beginning and 2, 4, 6, 8 weeks of experiment. Results (1)The body mass change trends were significant between the two groups at different time points(P<0.05). The body mass gain of rats in NE group was greatly less than that of the NC rats. (2)Regardless of the impact of time, the main effects in sucrose preference test were significantly different between the two groups (P<0.01). The change trends of sucrose preference were significantly different between the two groups at different time points(P<0.05), with the percentage of sucrose preference of NE rats greatly decreased with time. (3) The tension stimulation score and pain score of handling test in NE rats were significantly higher than those in NC rats(P<0.05 or P<0.01). (4) The horizontal and vertical movement abilities in NE rats were significantly decreased with the noise exposure period compared with the control group; the effects of time, groups and interaction were all significantly different (P<0.05 or P<0.01). Conclusion Continuous low frequency noise can lead to decrease of body weight and movement ability of rats, accompanied by emotional reactions such as anxiety and depression, and the severities of the changes are closely related to exposure time. |
| Key words: noise low frequency continuty emotions behavior |
