Bile acids, as one of the constituents of bile, can promote the digestion and absorption of fat and cholesterol metabolism. Studies find that bile acid is a signal molecule that not only combines with nuclear hormone receptors such as farnesoid X receptor, and G protein coupled bile acid receptor 5, to regulate their own metabolism, but also plays an important role in diabetes, obesity, non-alcoholic fatty liver disease and other metabolic diseases. The research on its mechanism will provide a solid theoretical basis for the diagnosis and treatment of metabolic diseases. In this review, we summarized the research progress of bile acids in glucolipid metabolic diseases.