| 摘要: |
| DNA甲基化作为表观遗传最常见的修饰形式之一，与哮喘的发生密切相关，虽然其本身不改变基因的序列，但可以在 DNA甲基转移酶的作用下使CpG二核苷酸5'端的胞嘧啶转变为甲基胞嘧啶，参与基因表达的调控，进而导致疾病的发生、发展。本文将综述近年相关文献，从诱发因素和作用机制等方面归纳和探讨DNA甲基化与哮喘的研究进展。 |
| 关键词: 哮喘 表观遗传学 DNA甲基化 屋尘螨 |
| DOI：10.16781/j.0258-879x.2017.02.0220 |
| 投稿时间：2016-09-27修订日期：2016-12-15 |
| 基金项目:国家自然科学基金（81570020），教育部留学回国人员科研启动基金，浙江省公益技术应用研究计划项目（2016C33216），湖南省教育厅重点科研项目（16A152），浦东新区科技发展基金（PKJ2016-Y49）. |
|
| DNA methylation and asthma: recent progress |
| WAN Li-ping,LI Sha,SHANG Yan*,BAI Chong |
(Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| DNA methylation is one of the most common forms of epigenetic modification, and it is closely related to the development of bronchial asthma, but its mechanism is unclear. Without altering the sequences of genes, DNA methylation can transfer the cytosine on the 5' end of CpG dinucleotide into methyl cytosine by DNA methyltransferase. Hence, DNA methylation can regulate gene expression, leading to the development and progression of diseases. In this review, we summarized the roles of DNA methylation in bronchial asthma, including related predisposing factors and mechanisms of action. |
| Key words: asthma epigenetics DNA methylation house dust mite |
