| 摘要: |
| 炎症与氧化应激是多种疾病病理过程的2个方面，它们互相促进，造成疾病的恶性循环。富氢水是富含氢气的水，研究表明，富氢水可选择性清除过量羟自由基，有效减轻机体氧化损伤，在不同病理状态下减轻组织的炎性损伤。近年来研究发现，富氢水可以改善类风湿关节炎、结肠炎、肝炎、胰腺炎等多种炎性状态，其抗炎作用的发挥与减轻氧化应激损伤和参与p38-MAPK、NF-κB等信号转导通路的调控有关。本文就富氢水的抗炎活性及其作用机制作一综述。 |
| 关键词: 氢 富氢水 炎性疾病 抗炎活性 抗氧化活性 信号通路 |
| DOI：10.16781/j.0258-879x.2020.07.0798 |
| 投稿时间：2019-10-07修订日期：2020-03-03 |
| 基金项目:上海市科技兴农项目（2019-02-08-00-08-F01154）. |
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| Anti-inflammatory activity and molecular mechanisms of hydrogen-rich water: recent progress |
| JIANG Jing,ZHANG Yao,JIANG Rui,LI Ya-ting,SONG Li-hua* |
(Department of Food Science&Technology, Shanghai Jiao Tong University School of Agriculture and Biology, Shanghai 200240, China
*Corresponding author) |
| Abstract: |
| Inflammation and oxidative stress are two aspects of the pathology of many diseases, and they also promote each other, causing a vicious cycle of the disease. Hydrogen-rich water is the water rich in hydrogen. Studies have proved that hydrogen-rich water can selectively reduce hydroxyl radicals and ameliorate oxidative and inflammatory injuries to organs and tissues under different pathological conditions. In recent years, it has been found that hydrogen-rich water can improve the inflammatory conditions of rheumatoid arthritis, colitis, hepatitis, pancreatitis, etc. Its anti-inflammatory effects are related to the amelioration of oxidative stress and regulation of the signal transduction pathways such as p38-mitogen-activated protein kinase (p38-MAPK) and nuclear factor κB (NF-κB). In the present review, the anti-inflammatory activity of hydrogen-rich water and its molecular mechanisms are summarized and discussed. |
| Key words: hydrogen hydrogen-rich water inflammatory diseases anti-inflammatory activity antioxidant activity signaling pathway |
