| 摘要: |
| 胃癌是威胁人类健康的主要恶性肿瘤之一，其发生涉及多步骤、多基因的相互作用过程。上皮间质转化（EMT）是上皮细胞通过特定程序转化为有间质表型细胞的过程。研究表明长链非编码RNA（lncRNA）可以通过与靶蛋白结合、作为竞争性内源RNA竞争微RNA等方式促进或抑制EMT过程，且许多特异表达的EMT相关lncRNA与胃癌的侵袭、转移密切相关。本文主要就EMT相关lncRNA在胃癌侵袭和转移中的调控机制作一综述。 |
| 关键词: 上皮间质转化 长链非编码RNA 胃肿瘤 肿瘤侵袭 肿瘤转移 |
| DOI：10.16781/j.0258-879x.2019.02.0209 |
| 投稿时间：2018-07-15修订日期：2018-09-18 |
| 基金项目:国家自然科学基金（81472277）. |
|
| Epithelial-mesenchymal transition-related long non-coding RNA and gastric cancer |
| LI Jiang,YUAN Shi-jie,NIE Ming-ming* |
(Department of General Surgery, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Gastric cancer is one of the main malignancies threatening human health, and its occurrence involves multistep and multigene interactions. Epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells transform to mesenchymal phenotypic cells through specific procedures. Studies have shown that long non-coding RNAs (lncRNAs) can promote or inhibit EMT by binding to target proteins and competing microRNAs as competitive endogenous RNAs, and some specific EMT-related lncRNAs are deeply involved in the invasion and metastasis of gastric cancer. In this review, we summarized the recent mechanisms of EMT-related lncRNAs in the regulating the invasion and metastasis of gastric cancer. |
| Key words: epithelial-mesenchymal transition long non-coding RNA stomach neoplasms neoplasm invasiveness neoplasm metastasis |
