| 摘要: |
| 真核细胞中蛋白磷酸酶（protein phosphatase）参与细胞分裂、凋亡，调控细胞周期，参与许多信号转导过程并发挥重要生物学功能。在天然免疫应答中，当病毒入侵机体后，多种蛋白磷酸酶能够通过控制其中关键蛋白的磷酸化水平，调控抗病毒免疫应答反应。本文将分别介绍丝/苏氨酸蛋白磷酸酶、酪氨酸蛋白磷酸酶和脂类磷酸酶在抗病毒天然免疫应答中的调控作用。 |
| 关键词: 蛋白磷酸酶 Ⅰ型干扰素 抗病毒反应 天然免疫 |
| DOI：10.16781/j.0258-879x.2017.06.0769 |
| 投稿时间：2016-12-10修订日期：2017-02-21 |
| 基金项目:国家自然科学基金（81422021） |
|
| Role of protein phosphatase in regulating antiviral innate immune response |
| ZHANG Yun-kai,ZHOU Qing-qing,CHEN Xiang,LIU Xing-guang* |
(National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Protein phosphatases play critical roles in regulating cell division, cell apoptosis, and cell cycle in eukaryotic cells, participating in numerous signal transduction processes and exerting a large amount of significant biological functions. A variety of protein phosphatases are identified to maintian the phosphorylation level of key proteins with a moderate level in the antiviral innate immune response to virus infection. In this paper, we reviewed the roles of serine/threonine protein phosphatases, tyrosine protein phosphatases, and lipid phosphatases in regulating antiviral innate immune responses. |
| Key words: protein phosphatase interferon type Ⅰ antiviral responses natural immunity |
