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| 染色体多态性不影响体外受精胚胎移植技术的生殖结局 |
| 松迪1,印惠荣1,张慧琴1,孙燕华1,沈晨晨1,杜惠1,施敏凤1,孙兆贵2*,孙方臻1,3* |
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(1. 第二军医大学长海医院生殖医学中心, 上海 200433;
2. 上海市计划生育科学研究所, 国家人口和计划生育委员会计划生育药具重点实验室, 上海 200032;
3. 中国科学院遗传与发育生物学研究所, 北京 100101
*通信作者) |
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| 摘要: |
| 目的 探讨染色体多态性对体外受精/卵胞质内单精子显微注射-胚胎移植（IVF/ICSI-ET）助孕患者临床妊娠结局的影响。方法 回顾性分析2015年3月-2016年6月在第二军医大学长海医院生殖医学中心首次进行IVF/ICSI-ET周期不孕不育夫妻的临床资料。根据夫妻一方或双方染色体是否存在多态性分为2组：染色体多态性组（夫妻一方或双方存在染色体多态性）和染色体正常组（夫妻双方染色体均正常）。比较分析两组夫妻在IVF/ICSI-ET治疗后的胚胎种植率、临床妊娠率、早期流产率和每移植周期活产率。结果 共纳入1 108对行IVF/ICSI-ET助孕的不孕不育夫妻，其中染色体多态性组69对，染色体正常组1 039对。染色体正常组和染色体多态性组的胚胎种植率（34.91% vs 34.62%，P>0.05）、临床妊娠率（49.09% vs 50.72%，P>0.05）、早期流产率（11.37% vs 8.57%，P>0.05）、每移植周期活产率（41.67% vs 43.47%，P>0.05）差异均无统计学意义。结论 染色体多态性不影响IVF/ICSI-ET助孕患者的临床结局。 |
| 关键词: 染色体多态性 体外受精 卵胞浆内单精子显微注射 胚胎移植 妊娠结局 |
| DOI：10.16781/j.0258-879x.2017.07.0836 |
| 投稿时间：2017-04-19修订日期：2017-06-22 |
| 基金项目: |
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| Chromosomal polymorphisms do not affect outcome of in vitro fertilization and embryo transfer treatment |
| SONG Di1,YIN Hui-rong1,ZHANG Hui-qin1,SUN Yan-hua1,SHEN Chen-chen1,DU Hui1,SHI Min-feng1,SUN Zhao-gui2*,SUN Fang-zhen1,3* |
(1. Reproductive Medicine Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. Shanghai Institute of Planned Parenthood Research, Key Laboratory of Contraceptive Drugs and Devices of National Population and Family Planning Commission of China, Shanghai 200032, China;
3. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
*Corresponding authors) |
| Abstract: |
| Objective To explore the effect of chromosomal polymorphic variations on the outcome of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) treatment for infertile couples. Methods In this retrospective study, 1 108 infertile couples, who received their first IVF/ICSI-ET treatment cycles in Reproductive Medicine Center of Changhai Hospital of Second Military Medical University from Mar. 2015 to Jun. 2016, were included and divided into two groups:normal chromosomal group (the infertile couples with normal chromosome) and chromosomal polymorphic group (with chromosomal polymorphic variations). The embryo implantation rate, clinical pregnancy rate (CPR), early abortion rate and live birth rate (LBR) after IVF/ICSI-ET treatment were compared and analyzed. Results A total of 1 108 infertile couples received IVF/ICSI-ET treatment were enrolled, with 69 in the chromosomal polymorphic group, and 1 039 in the normal chromosomal group. There were no significant differences between the two groups in embryo implantation rate (34.91% vs 34.62%, P>0.05), CPR (49.09% vs 50.72%, P>0.05), early abortion rate (11.37% vs 8.57%, P>0.05) or LBR (41.67% vs 43.47%, P>0.05). Conclusion Chromosomal polymorphisms appear to have no effect on the outcome of IVF/ICSI-ET treatment for infertile couples. |
| Key words: chromosome polymorphism fertilization in vitro intracytoplasmic sperm injection embryo transfer pregnancy outcome |
