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周铁,Guiting LIN,Tom F. LUE.低强度体外冲击波疗法激活精原干细胞在无精症中的应用展望[J].第二军医大学学报,2020,41(4):444-448 [点击复制]
ZHOU Tie,Guiting LIN,Tom F. LUE.Application and prospect of low-intensity extracorporeal shock wave therapy in activating the spermatogonial stem cells for azoospermia[J].Acad J Sec Mil Med Univ,2020,41(4):444-448 [点击复制]

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低强度体外冲击波疗法激活精原干细胞在无精症中的应用展望
周铁¹,GuitingLIN²,TomF.LUE^2*
0 字体:加大+\|默认\|缩小-
(1. 海军军医大学(第二军医大学)长海医院泌尿外科, 上海 200433; 2. 美国加州大学旧金山分校泌尿外科, 旧金山 94143-0738 ^*通信作者)

摘要:

低强度体外冲击波疗法（LI-ESWT）作为物理医学的一个代表具有多疾病、多方向的应用潜力，近年研究显示LI-ESWT可以招募、激活内源性干细胞。用LI-ESWT激活精原干细胞可给原发性非梗阻性无精症和医源性无精症患者的治疗带来新突破。本文拟对LI-ESWT激活精原干细胞治疗无精症的应用进行展望。

关键词: 低强度体外冲击波治疗干细胞男性不育生育力保存无精子症

DOI：10.16781/j.0258-879x.2020.04.0444

投稿时间：2019-04-19修订日期：2020-03-25

基金项目:国家科技重大专项（2017ZX09304030）.

Application and prospect of low-intensity extracorporeal shock wave therapy in activating the spermatogonial stem cells for azoospermia

ZHOU Tie¹,Guiting LIN²,Tom F. LUE^2*

(1. Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Urology, University of California, San Francisco, San Francisco 94143-0738, California, USA
^*Corresponding author)

Abstract:

Low-intensity extracorporeal shock wave therapy (LI-ESWT) as a representative of physical medicine has the application potentials in multiple diseases and orientations. Recent studies have found that LI-ESWT can also be used to enroll and activate endogenous stem cells. Activating the spermatogonial stem cells with LI-ESWT may bring a new breakthrough to the treatment of the patients with idiopathic non-obstructive azoospermia and latrogenic obstructive azoospermia. This article reviews the application and prospect of LI-ESWT in activating the spermatogonial stem cells for azoospermia.

Key words: low-intensity extracorporeal shock wave therapy stem cells infertility fertility preservation azoospermia