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  • 孔晨,张春鹏,李柏.耳穴贴压治疗胃癌SOX化学治疗方案相关恶心、呕吐和腹泻的疗效观察[J].第二军医大学学报,2018,39(5):493-498    [点击复制]
  • KONG Chen,ZHANG Chun-peng,LI Bai.Curative effect of auricular point sticking for SOX chemotherapy-induced nausea, vomiting and diarrhea[J].Acad J Sec Mil Med Univ,2018,39(5):493-498   [点击复制]
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耳穴贴压治疗胃癌SOX化学治疗方案相关恶心、呕吐和腹泻的疗效观察
孔晨1△,张春鹏2△,李柏1*
0
(1. 海军军医大学(第二军医大学) 长海医院康复医学科, 上海 200433;
2. 海军军医大学(第二军医大学) 长海医院针灸科, 上海 200433
共同第一作者
*通信作者)
摘要:
目的 探讨耳穴贴压在治疗胃癌SOX(奥沙利铂+替吉奥)化学治疗方案相关恶心、呕吐和腹泻中的价值。方法 将胃癌根治术后接受SOX化学治疗方案治疗的110例胃癌患者随机分为试验组和对照组,每组55例。两组均接受耳穴贴压,但选择的耳穴穴位不同。试验组选择与胃肠功能相关的耳穴穴位,包括神门、胃、交感、皮质下、脾和肝;对照组选取与胃肠功能无关的耳穴穴位,包括眼、肺、肾、肩关节和膝关节。耳穴贴压持续21 d,患者每天按压相关耳穴3次,每次不少于3 min。采用《美国国家癌症研究所化学治疗药副作用评价标准2.0》评估患者恶心、呕吐和腹泻的严重程度。结果 共95例患者完成研究,其中试验组49例、对照组46例。两组患者的年龄、性别、体质量指数、吸烟史、饮酒史、肿瘤浸润深度、局部淋巴结转移、远处转移、肿瘤分期和肿瘤最大径等差异均无统计学意义。试验组恶心、呕吐和腹泻的发生率与和对照组相比差异无统计学意义,但恶心、呕吐和腹泻的严重程度和持续时间均小于对照组(P均<0.05)。结论 耳穴贴压可以有效降低胃癌患者口服SOX化学治疗药相关恶心、呕吐和腹泻的严重程度及持续时间。
关键词:  胃肿瘤  药物疗法  耳穴贴压  恶心  呕吐  腹泻
DOI:10.16781/j.0258-879x.2018.05.0493
投稿时间:2018-03-01修订日期:2018-03-01
基金项目:
Curative effect of auricular point sticking for SOX chemotherapy-induced nausea, vomiting and diarrhea
KONG Chen1△,ZHANG Chun-peng2△,LI Bai1*
(1. Department of Rehabilitation Medicine, Changhai Hospital, Navy Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Acupuncture and Moxibustion, Changhai Hospital, Navy Medical University (Second Military Medical University), Shanghai 200433, China
Co-first authors.
*Corresponding author)
Abstract:
Objective To explore the value of auricular point sticking in the treatment of nausea, vomiting and diarrhea induced by SOX (S-1 and oxaliplatin) chemotherapy in the patients with gastric cancer. Methods Totally 110 gastric cancer patients receiving SOX chemotherapy after radical gastrectomy were recruited and equally allocated into experiment group and control group, with 55 cases in each group. The patients in the two groups received auricular point sticking at different acupoints. The shenmen, stomach, sympathetic, subcortex, liver and spleen were selected for the experiment group, while the acupoints in the control group included the eye, lung, kidney, shoulder joint and knee point. Auricular point sticking therapy continued for 21 days in all patients, who pressed the auricular points 3 times a day for at least 3 min each time. American National Cancer Institute-Common Toxicity Criteria (Version 2.0) was applied to evaluate the severity of nausea, vomiting and diarrhea. Results Ninety-five patients finished the study with 49 in the experiment group and 46 in the control group. There were no significant differences in age, gender, body mass index, smoking history, drinking history, invasion depth, regional lymph node metastasis, distant metastasis, tumor stage or tumor maximum diameter between the two groups. The incidence of nausea, vomiting and diarrhea was similar in the two groups. The patients had lower severity and shorter duration of nausea, vomiting and diarrhea in the experiment group versus the control group (all P<0.05). Conclusion Auricular point sticking feasibly decreases the severity and duration of nausea, vomiting and diarrhea of gastric cancer patients receiving SOX chemotherapy.
Key words:  stomach neoplasms  drug therapy  auricular point sticking  nausea  vomiting  diarrhea