Objective To explore the clinical value of neutrophil-to-lymphocyte ratio (NLR) in predicting prognosis of the patients with intracerebral hemorrhage (ICH). Methods A total of 226 patients who admitted to Changhai Hospital of Navy Medical University (Second Military Medical University) from Jan. 2013 to Aug. 2014 were enrolled in this study, including 126 patients with first-ever ICH and 100 patients with hypertension (control). The counts of white blood cell (WBC), neutrophil, and lymphocyte were analyzed, and NLR value was calculated. The receiver operating characteristic (ROC) curve was used to evaluate the prognostic indicators of ICH, and the multivariate logistic regression model was used to analyze the influencing factors for the prognosis of the ICH patients. Results The WBC count and NLR value were significantly greater in the ICH patients than those in the hypertension patients (both P<0.01). The ICH patients with modified Rankin scale (mRS) score of 3-6 (n=32) had significantly greater counts of WBC and neutrophil, and NLR value versus those with mRS score of 0-2 (n=94, all P<0.05). And the ICH patients with large hematoma (hematoma volume ≥ 30 mL, n=42) had significantly greater neutrophil count and NLR value versus those with small hematoma (<30 mL, n=84; both P<0.05). When 3.001 was accepted as a cut-off value for NLR predicting prognosis, the sensitivity and the specificity were 64.5% and 83.3%, respectively. Multivariate logistic regression analysis revealed that NLR was an independent predictor for ICH prognosis. Conclusion NLR may be used as an indicator to evaluate the prognosis of ICH.