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  • 张煜,李宁,刘晓红,徐志云*.非编码RNA在钙化性主动脉瓣疾病发生、发展中的作用[J].第二军医大学学报,2019,40(7):782-787    [点击复制]
  • ZHANG Yu,LI Ning,LIU Xiao-hong,XU Zhi-yun*.Research progress on non-coding RNA in calcific aortic valve disease[J].Acad J Sec Mil Med Univ,2019,40(7):782-787   [点击复制]
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非编码RNA在钙化性主动脉瓣疾病发生、发展中的作用
张煜,李宁,刘晓红,徐志云*
0
(海军军医大学(第二军医大学)长海医院心血管外科, 上海 200433
*通信作者)
摘要:
钙化性主动脉瓣疾病是一个涉及内皮损伤、慢性炎症、细胞外基质重塑、细胞表型分化及细胞凋亡等复杂病理变化的过程。主动脉瓣主要由内部的瓣膜间质细胞及其表面覆盖的瓣膜内皮细胞构成,此两类细胞均参与了钙化性主动脉瓣疾病的病理进程。非编码RNA主要通过转录后调控机制参与心血管疾病病理生理过程,可能在钙化性主动脉瓣疾病的发生、发展中起着重要作用。
关键词:  钙化性主动脉瓣疾病  瓣膜间质细胞  瓣膜内皮细胞  非编码RNA
DOI:10.16781/j.0258-879x.2019.07.0782
投稿时间:2018-11-27修订日期:2019-03-22
基金项目:
Research progress on non-coding RNA in calcific aortic valve disease
ZHANG Yu,LI Ning,LIU Xiao-hong,XU Zhi-yun*
(Department of Cardiovascular Surgery, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Calcific aortic valve disease is a process involving complex pathological changes such as endothelial injury, chronic inflammation, extracellular matrix remodeling, cell phenotype differentiation and apoptosis. The aortic valve is mainly composed of internal valve interstitial cells and external valve endothelial cells, and they are all involved in the pathological process of calcific aortic valve disease. Non-coding RNA participates in the pathophysiological process of cardiovascular disease mainly through post-transcriptional regulation mechanism, and may play an important role in the development and progression of calcific aortic valve disease.
Key words:  calcific aortic valve disease  valve interstitial cells  valve endothelial cells  non-coding RNA