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朱开鑫,侯立军*.脑损伤后阵发性交感神经过度兴奋的发病机制[J].第二军医大学学报,2019,40(11):1231-1235 [点击复制]
ZHU Kai-xin,HOU Li-jun*.Progress in pathogenesis of paroxysmal sympathetic hyperactivity after brain injury[J].Acad J Sec Mil Med Univ,2019,40(11):1231-1235 [点击复制]

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脑损伤后阵发性交感神经过度兴奋的发病机制
朱开鑫,侯立军*
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(海军军医大学(第二军医大学)长征医院神经外科, 上海 200003 ^*通信作者)

摘要:

阵发性交感神经过度兴奋（PSH）对脑损伤患者预后影响较大，目前对于PSH的发病机制研究还不透彻。本文回顾了PSH的病因，包括创伤性脑损伤、缺氧性脑损伤、脑血管相关的脑损伤、颅脑感染、抗N-甲基-D-天冬氨酸受体脑炎和其他一些较少见的病因。本文还介绍了有关PSH发病机制的癫假说、断连假说和新提出的神经内分泌假说，为PSH的深入研究提供参考。

关键词: 阵发性交感神经过度兴奋脑损伤脑炎发病机制

DOI：10.16781/j.0258-879x.2019.11.1231

投稿时间：2019-05-13修订日期：2019-08-13

基金项目:国家自然科学基金（81671206），军队后勤科研重大项目（AWS175003）.

Progress in pathogenesis of paroxysmal sympathetic hyperactivity after brain injury

ZHU Kai-xin,HOU Li-jun*

(Department of Neurosurgery, Changzheng Hospital, Naval Medical University(Second Military Medical University), Shanghai 200003, China
^*Corresponding author)

Abstract:

Paroxysmal sympathetic hyperactivity (PSH) has a profound impact on the prognosis of patients suffering from brain injury, but the research on pathogenesis in relation to PSH is limited. In this paper, the etiologies of PSH, including traumatic brain injury, hypoxic brain injury, cerebrovascular-related brain injury, craniocerebral infection, anti-N-methyl-D-aspartate receptor encephalitis, and a number of rare etiological factors were reviewed. The epilepsy hypothesis, disconnection hypothesis and new-presented neuroendocrine hypothesis about the pathogenesis of PSH were introduced, so as to provide reference for further research on PSH.

Key words: paroxysmal sympathetic hyperactivity brain injuries encephalitis pathogenesis