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  • 贺海威,王静,徐明娟*.长链非编码RNA在宫颈癌发生、发展中的机制[J].第二军医大学学报,2019,40(10):1124-1129    [点击复制]
  • HE Hai-wei,WANG Jing,XU Ming-juan*.Long non-coding RNAs in development and progression of cervical cancer: mechanism research status[J].Acad J Sec Mil Med Univ,2019,40(10):1124-1129   [点击复制]
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长链非编码RNA在宫颈癌发生、发展中的机制
贺海威,王静,徐明娟*
0
(海军军医大学(第二军医大学)长海医院妇产科, 上海 200433
*通信作者)
摘要:
宫颈癌是女性第二常见的恶性肿瘤,是发展中国家女性恶性肿瘤死亡的第三大主要原因,早期诊断和治疗是有效治疗宫颈癌、改善预后的关键。由于其复杂性,宫颈癌的发生、发展机制仍然是研究者亟需攻克的难题。近年来,大量研究表明长链非编码RNA(lncRNA)在肿瘤发生、发展中起着重要作用。本文围绕人乳头瘤病毒(HPV)型E6和E7癌蛋白相关机制、lncRNA性质相关机制和肿瘤发生、发展中常见信号通路相关机制,对宫颈癌机制网络中lncRNA的作用进行综述,为筛查宫颈癌早期诊断和治疗中可用的潜在标志物提供参考。
关键词:  长链非编码RNA  宫颈肿瘤  信号转导通路  微RNA
DOI:10.16781/j.0258-879x.2019.10.1124
投稿时间:2019-05-13修订日期:2019-06-26
基金项目:国家重点研发计划(2016YFC1303100).
Long non-coding RNAs in development and progression of cervical cancer: mechanism research status
HE Hai-wei,WANG Jing,XU Ming-juan*
(Department of Gynaecology and Obstetrics, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Cervical cancer is the second most commonly seen cancer in women and the third leading cause of cancer death in developing countries. Early diagnosis and treatment are the keys to the effective treatment of cervical cancer and the improvement of prognosis. Because of the complexity, the mechanism of development and progression of cervical cancer is still an urgent problem to solve. Recently, quantity of studies have shown that long non-coding RNAs (lncRNAs) play important roles in tumor development and progression. In this review, we sumed up the multiple effects of lncRNAs in cervical cancer, focusing on the related mechanisms of human papilloma virus (HPV) E6 and E7 oncoprotein, the nature of lncRNAs and the signaling pathway in the development and progression of cervical cancer. And we further expounded the cervical cancer mechanism network, providing reference for screening the potential markers for early diagnosis and treatment of cervical cancer.
Key words:  long non-coding RNAs  uterine cervical neoplasms  signaling pathway  microRNAs