| 摘要: |
| 目的 观察复方磺胺嘧啶锌凝胶治疗下肢静脉性溃疡的疗效。方法 选择2015年1月至2019年12月于我院就诊的下肢静脉性溃疡患者，包括尚未行手术治疗的门诊换药患者40例和手术治疗患者40例。采用随机数字表法将未手术患者随机分为未手术试验组（20例）及未手术对照组（20例），将手术治疗患者随机分为手术试验组（20例）及手术对照组（20例）。试验组患者常规碘伏换药后复方磺胺嘧啶锌凝胶敷于下肢溃疡处，对照组患者常规碘伏换药后利凡诺纱布敷于下肢溃疡处。观察并比较各组患者在治疗不同时间点的溃疡面积缩小率和溃疡愈合率。结果 未手术试验组患者治疗1、2、3周时的溃疡面积缩小率均高于未手术对照组（P均<0.01）。手术试验组患者治疗1、2、3、4周时的溃疡面积缩小率与手术对照组相比，差异均无统计学意义（P均>0.05）。治疗2和4周时的溃疡愈合率手术试验组与手术对照组比较，差异均无统计学意义（P均>0.05）。未手术试验组、对照组患者治疗3周时的溃疡愈合率分别为0、5%（1/20），两组差异无统计学意义（P>0.05）。结论 复方磺胺嘧啶锌凝胶具有促进下肢静脉性溃疡愈合的作用，在尚未手术的保守治疗患者中，常规换药后复方磺胺嘧啶锌凝胶外敷的疗效优于常规换药后利凡诺外敷。 |
| 关键词: 复方磺胺嘧啶锌凝胶 静脉性溃疡 腿溃疡 溃疡愈合 |
| DOI：10.16781/j.0258-879x.2021.04.0461 |
| 投稿时间：2020-02-16修订日期：2020-09-27 |
| 基金项目:广西壮族自治区卫生和计划生育委员会自筹经费科研课题（z20170883）. |
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| Application of compound sulfadiazine zinc gel in treating venous leg ulcers |
| LIAO Yu-ping,GUO Jian-gang,KONG Xiang-wei,WANG Xing-hai* |
(Department of Vascular Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
*Corresponding author) |
| Abstract: |
| Objective To observe the efficacy of compound sulfadiazine zinc gel in the treatment of venous leg ulcers. Methods Patients with venous leg ulcer were selected in our hospital from Jan. 2015 to Dec. 2019, including 40 outpatients with dressing change without surgical treatment and 40 patients with surgical treatment. The outpatients were randomly divided into non-surgical experimental group (n=20) and non-surgical control group (n=20), and the patients with surgical treatment were divided into surgical experimental group (n=20) and surgical control group (n=20) by random number tables. Compound sulfadiazine zinc gel was applied to the leg ulcers after routine iodophor dressing in both experimental groups, while rivanol gauze was applied in both control groups. The ulcer area reduction rate and the ulcer healing rate in each group were observed and compared at different time points. Results The ulcer area reduction rates in the non-surgical experimental group were significantly higher than those in the non-surgical control group after 1, 2, and 3 weeks of treatment (all P<0.01). The ulcer area reduction rates in the surgical experimental group were similar to those in the surgical control group after 1, 2, 3, and 4 weeks of treatment (all P>0.05). There was no significant difference in the healing rate between the surgical experimental group and the surgical control group at 2 or 4 weeks of treatment (both P>0.05). The ulcer healing rate was 0 in the non-surgical experimental group and 5% (1/20) in the non-surgical control group after 3 weeks of treatment, with no significant difference between the two groups (P>0.05). Conclusion Compound sulfadiazine zinc gel can promote the healing of venous ulcers in the lower limbs. In patients with conservatively treated venous ulcers receiving no surgery, the efficacy of external application of compound sulfadiazine zinc gel is better than that of rivanol after routine dressing change. |
| Key words: compound sulfadiazine zinc gel venous ulcers leg ulcer ulcer healing |
