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| 基于肿瘤缺氧微环境促进肿瘤治疗的纳米递送策略 |
| 李鹃鹃1,韩治敏1,宫春爱2,李国瑞1,陈昕璐1,高申1* |
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(1. 海军军医大学(第二军医大学)第一附属医院药学部, 上海 200433;
2. 上海交通大学医学院附属第九人民医院药剂科, 上海 200011
*通信作者) |
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| 摘要: |
| 缺氧是肿瘤微环境的重要特征之一，主要由肿瘤组织供氧与耗氧的不平衡引起。缺氧状态对肿瘤的生长和转移有着极其重要的影响，会引发化学治疗耐药、放射治疗抵抗等，因此也被认为是肿瘤治疗的主要障碍之一。肿瘤微环境内独有的缺氧的特点使得缺氧成为肿瘤治疗的有效靶点。纳米技术具有靶向性高、组织相容性好等特性，在肿瘤治疗领域具有广阔的应用前景。本文综述了近年来基于缺氧微环境的新型纳米递送系统在肿瘤化学治疗、放射治疗、光动力治疗和免疫治疗等方面的研究进展。 |
| 关键词: 抗肿瘤药 靶向治疗 缺氧 纳米技术 肿瘤微环境 肿瘤抗药性 |
| DOI：10.16781/j.CN31-2187/R.20200763 |
| 投稿时间：2020-05-22修订日期：2020-09-27 |
| 基金项目:国家自然科学基金（81972891），国家临床重点专科-临床药学军队建设项目，上海市科学技术委员会基础研究项目（18JC1414200）. |
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| Nano-delivery systems based on hypoxic microenvironment in tumor therapy: an up-to-date review |
| LI Juan-juan1,HAN Zhi-min1,GONG Chun-ai2,LI Guo-rui1,CHEN Xin-lu1,GAO Shen1* |
(1. Department of Pharmacy, The First Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
*Corresponding author) |
| Abstract: |
| Hypoxia is one of the important features of tumor microenvironment, and it is mainly caused by the imbalance between oxygen supply and oxygen consumption of tumor tissues. Hypoxia has an extremely important effect on tumor growth and metastasis, such as triggering drug resistance and radiation resistance, so it has always been regarded as a major obstacle to tumor treatment. Meanwhile, hypoxic microenvironment is becoming a favorable target for tumor therapy because of its uniqueness in tumor site. Nanotechnology has high targeting ability and good histocompatibility, and has been widely applied in tumor therapy. This review summarizes recent advances in new nano-delivery systems based on hypoxic microenvironment in tumor chemotherapy, radiotherapy, photodynamic therapy and immunotherapy. |
| Key words: antineoplastic agents targeted therapy hypoxia nanotechnology tumor microenvironment neoplasm drug resistance |
