ObjectiveTo detect the change of renal parenchyma stiffness in renal amyloidosis patients with amyloid sound touch elastography (STE), and to explore its clinical value.MethodsTwenty-eight patients with renal amyloidosis confirmed by biopsy and 28 healthy controls were prospectively enrolled. All subjects of the 2 groups underwent STE measurement of central parenchyma of the left kidney. The STE values of the 2 groups were compared, and the potential evaluation value of STE values for renal involvement in amyloidosis patients was analyzed.ResultsThe STE value of central parenchyma of the left kidney in the renal amyloidosis group was (12.55±4.10) kPa, while that in the control group was (7.76±1.42) kPa, and the difference was statistically significant (t＝5.842, P＝0.001). Logistic regression analysis showed that, after adjusting for age and gender, STE value was positively correlated with the risk of renal amyloidosis (odds ratio＝2.58, 95% confidence interval 1.48-4.50, P＝0.001).ConclusionSTE value is an effective evaluation index of renal involvement in patients with amyloidosis, and has potential value in disease monitoring, treatment efficacy evaluation and prognosis assessment among these patients.