In June 2021, National Health Commission and other 9 ministries decided to implement the Project to Reduce Millions of New Disabilities for prevention and treatment of stroke (Million Disability Reduction Project), and jointly formulated Comprehensive Plan for Strengthening Stroke Prevention and Treatment to Reduce Millions of New Disabilities. Million Disability Reduction Project is an important part of efforts for national stroke prevention and treatment, is the key job in cerebrovascular disease control in China in the future, and needs to be actively promoted by all levels of medical institutions according to their own conditions. This article elaborates on the background and significance of the project and the job that needs to be focused on, so as to comprehensively understand and recognize the meaning of the Million Disability Reduction Project, better guide the development of the related jobs in the future, and reduce the disability rate, social risk and family burden of stroke.