Objective To explore the influencing factors of minor amputation in lower limb arteriosclerosis obliterans (LLASO) patients with foot ulcer.Methods The clinical data of 179 LLASO patients with foot ulcer who were admitted to Department of Vascular Surgery,Shanghai Traditional Chinese Medicine-Integrated Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from Jan.1 to Dec.30,2020 were retrospectively analyzed.Univariate and multivariate analyses were used to screen the potential high-risk factors of amputation in LLASO patients with foot ulcer,and Kaplan-Meier survival analysis was used to explore the relationship between high-risk factors and amputation survival.Results In 179 LLASO patients,41 minor amputations occurred during the follow-up period.Multivariate logistic regression analysis showed that low albumin level,high neutrophil to lymphocyte ratio (NLR),lipid-lowering therapy and ulcer site were the influencing factors of amputation in LLASO patients with foot ulcer (all P<0.05).After adjusting for the effects of age,Wagner classification and ulcer area,high NLR and plantar forefoot ulcer were independent influencing factors of amputation in LLASO patients with foot ulcer (odds ratio[OR]=8.211,95% confidence interval[CI]1.774-37.998,P=0.007;OR=2.919,95%CI 1.040-8.484,P=0.031).Kaplan-Meier survival analysis showed that the amputation-free survival time of patients in the high NLR group (NLR ≥ 2.00,n=136) was significantly shorter than that of those in the low NLR group (NLR<2.00,n=43)(8[5,9]months vs 11[7,15]months,P=0.020).Conclusion Low albumin level and high NLR are associated with amputation in LLASO patients with foot ulcer,and high NLR has predictive value for ulcer progression to amputation.