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| 当归补血汤化学成分及其促造血功能研究进展 |
| 陈威1,徐希科1,吕燕慧2,魏艳平2,丁倩倩3,王杰2,隗鑫曈2,李展鸿4,祖先鹏1* |
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(1. 海军军医大学(第二军医大学)药学系天然药物化学教研室, 上海 200433;
2. 山东中医药大学药学院药物分析教研室, 济南 250355;
3. 安徽中医药大学药学院天然药物化学教研室, 合肥 230012;
4. 广东药科大学药学院药物分析教研室, 广州 510640
*通信作者) |
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| 摘要: |
| 当归补血汤是补气生血的经典中药名方，具有促进造血、保护肾组织、调节免疫、抗纤维化、抗肿瘤及抗抑郁等作用。本文通过分析近15年关于当归补血汤促进造血功能的研究文献，总结了当归补血汤的化学成分，并从促进造血干细胞和外周血细胞的形成、抑制造血干细胞衰老、改善骨髓造血微环境、调节肠道菌群、调节免疫系统及调节髓外器官造血等方面综述当归补血汤对造血系统的影响。 |
| 关键词: 当归补血汤 化学成分 造血功能 造血干细胞 骨髓造血微环境 |
| DOI：10.16781/j.CN31-2187/R.20220003 |
| 投稿时间：2022-01-03修订日期：2022-04-29 |
| 基金项目:国家重点研发计划(2019YFC1711000),国家自然科学基金(82004215),上海市卫生健康委员会课题(20204Y0326),海军军医大学(第二军医大学)启航计划. |
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| Chemical components of Danggui Buxue decoction and its hematopoietic function: research progress |
| CHEN Wei1,XU Xi-ke1,Lü Yan-hui2,WEI Yan-ping2,DING Qian-qian3,WANG Jie2,WEI Xin-tong2,LI Zhan-hong4,ZU Xian-peng1* |
(1. Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Pharmaceutical Analysis, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China;
3. Department of Natural Medicinal Chemistry, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, Anhui, China;
4. Department of Pharmaceutical Analysis, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510640, Guangdong, China
*Corresponding author) |
| Abstract: |
| As a classic prescription of traditional Chinese medicine, Danggui Buxue decoction (DBD) is mainly used for invigorating qi and promoting blood, with the following specific functions: promoting hematopoiesis, protecting kidney tissue, regulating immunity, anti-fibrosis, anti-tumor, anti-depression and so on. Relevant studies in recent 15 years on promoting hematopoietic functions by DBD have been collected in this review. The chemical components of DBD were summarized and the influences of DBD on hematopoietic system were reviewed, with focus on promoting the formation of hematopoietic stem cells and peripheral blood cells, inhibiting the senescence of hematopoietic stem cells, improving the bone marrow hematopoietic microenvironment, and regulating intestinal flora, immune system and extramedullary organ hematopoiesis. |
| Key words: Danggui Buxue decoction chemical components hematopoietic function hematopoietic stem cells bone marrow hematopoietic microenvironment |
