Clear aligner therapy is a new orthodontic treatment. Its indications have been extended with the development of biomaterials and biomechanics. Compared with the traditional fixed orthodontic appliances, clear aligner therapy has attracted great attention in recent years because of the superior asthetics and comfort, the accuracy and predictability of digital planning, and long interval between each revisit. Clear aligner is mainly used for tooth movement, usually combined with conventional appliances for the treatment of early malocclusions in chilare involving many complexities such as the unpredictability of growth, dentition replacement monitoring, muscle functional adjustment, orthopedic treatment, etc. This article reviews the clinical application of clear aligners for early malocclusion in children, hoping to provide a new, simple, efficient and safe method for early orthodontic treatment.