| 摘要: |
| 核旁斑是细胞核内一类重要的亚核体。核旁斑可通过拘留RNA或蛋白以及与miRNA相互作用等方式调控基因的表达，从而在肿瘤发生、发展过程中发挥重要作用，研究核旁斑在肿瘤细胞中的生物学结构及作用对肿瘤的诊疗具有重要意义。目前关于核旁斑在肿瘤细胞中的结构、功能及临床意义尚未完全明确。本文综述了肿瘤细胞核旁斑的组成、结构、装配及其在肿瘤发生、发展过程的作用机制和临床意义，旨在为肿瘤的诊断、治疗及预后提供新的研究方向与线索。 |
| 关键词: 核旁斑 肿瘤 核富集常染色体转录本1 结构 功能 |
| DOI：10.16781/j.CN31-2187/R.20220351 |
| 投稿时间：2022-04-27修订日期：2023-03-07 |
| 基金项目:国家自然科学基金（81972657，81672345）. |
|
| Biological structure and function of paraspeckles in cancer cell: research progress |
| TAN Jian,WANG Yuefan,DAI Zhihui,YIN Haozan,WANG Sijie,YANG Fu* |
(Department of Medical Genetics, College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Paraspeckles are important subnuclear bodies in the nucleus. They can regulate gene expression by holding RNA or protein and interacting with miRNA, thus playing important roles in the development and progression of cancers. Studying the biological structure and function of paraspeckles in cancer cell is crucial for the diagnosis and treatment of cancers; however, the structure, function, and clinical significance of paraspeckles in cancer cell are still elusive. This paper reviews the composition, structure, and assembly of paraspeckles, and its mechanisms and clinical significance in the development and progression of cancers, so as to provide research directions and clues for the tumor diagnosis, treatment, and prognosis. |
| Key words: paraspeckles tumor nuclear enriched autosomal transcript 1 structure function |
