| 摘要: |
| 肝脏是维持人体代谢和解毒等功能的重要器官。当出现急慢性肝衰竭或基因缺陷，肝功能受损无法满足机体所需时，肝移植常作为治疗首选。然而，由于肝源短缺等问题，肝移植的应用受到限制，人们开始发展与肝细胞移植相关的治疗方法。肝细胞移植的可行性已在多种动物模型中得到证实，用于促进肝再生或减少肝脏纤维化的各种类型自体细胞移植的临床试验也已开始实践。本文重点回顾了肝细胞移植的主要临床适应证、移植细胞的来源选择及肝细胞移植的技术问题，以期推进肝细胞移植相关研究，使肝细胞移植在临床治疗中取得广泛收益，为供体器官短缺提供切实可行的解决策略。 |
| 关键词: 肝细胞 细胞移植 肝脏再生 代谢性肝病 肝衰竭 |
| DOI：10.16781/j.CN31-2187/R.20220518 |
| 投稿时间：2022-06-18修订日期：2022-12-18 |
| 基金项目:国家自然科学基金（81970453，82000483），上海市卫生健康委员会卫生行业临床研究专项青年项目（20214Y0360）. |
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| Hepatocyte transplantation: research progress |
| SHENG Jie,ZHANG Wen-li,LIU Fu-chen,WANG Min-jun,LIU Hui* |
(Department of Hepatic Surgery (Ⅲ), The Third Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200438, China
*Corresponding author) |
| Abstract: |
| The liver is an important organ that helps to maintain metabolism and detoxification function in the human body. Orthotropic liver transplantation (OLT) is recognized as the first therapeutic option for patients with end-stage liver disease or liver failure caused by acute or chronic liver failure or genetic defect. Hepatocyte transplantation, however, gradually emerges as a possible strategy to overcome the limitations of OLT, especially the lack of organ donors. To date, the feasibility of hepatocyte transplantation has been confirmed in various animal models, and clinical observations have demonstrated encouraging results in promoting liver regeneration or reducing liver fibrosis by autologous cell transplantation. This paper reviews the main clinical indications of hepatocyte transplantation, and focuses on obstacles and breakthroughs in new cell sources and transplantation technique in order to boost related research in this field, leading to wider application in clinic and providing fundamental solutions for the shortage of donor organs. |
| Key words: hepatocyte cell transplantation liver regeneration metabolic liver disease hepatic failure |
