| 摘要: |
| 青春期社会隔离作为一种应激源会导致动物和人类的社会行为以及神经内分泌系统网络功能改变。大量研究发现暴露于社会隔离压力会诱发大脑不同区域功能发生特异性改变，以及下丘脑-垂体-肾上腺轴的激活，多巴胺、5-羟色胺、γ-氨基丁酸、谷氨酸等神经递质的合成释放及其受体的敏感度改变，这些改变会诱发动物及人类出现不同程度的抑郁样行为，与抑郁症的发生密切相关。青春期是大脑神经网络、功能和化学重组的关键时期，相较于成年期社会隔离，青春期社会隔离会产生持续、难以逆转的消极影响，大大增加个体发生精神疾病的风险。本文就青春期社会隔离致抑郁的相关脑机制进行综述，探讨青春期社会隔离对大脑发育、内分泌、神经递质以及胶质细胞的特异影响，讨论其与抑郁发生的相关性。 |
| 关键词: 青春期 社会隔离 抑郁 脑机制 |
| DOI：10.16781/j.CN31-2187/R.20220938 |
| 投稿时间：2022-12-17修订日期：2023-09-08 |
| 基金项目: |
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| Brain mechanism of depressive behavior induced by social isolation in experimental animals during adolescence: research progress |
| QI Tian1,HU Ting2,WANG Wei2* |
(1. College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Military Stress Psychology, Faculty of Psychology, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| As a stressor, social isolation in adolescence can lead to changes in social behavior and neuroendocrine system network function of animals and humans. A large number of studies have found that exposure to social isolation stress can induce specific changes in the function of different areas of the brain, active the hypothalamic-pituitary-adrenal axis, synthesize and release neurotransmitters such as dopamine, serotonin, γ-aminobutyric acid, and glutamate, and change the sensitivity of their receptors. These changes can induce different degrees of depressive-like behavior in animals and humans, which is closely related to the occurrence of depression. Adolescence is a critical period for neural networks, function and chemical reorganization of the brain, and compared with social isolation in adulthood, adolescent social isolation has a sustained and irreversible negative impact, greatly increasing the risk of mental illness in individuals. This article reviews the brain mechanisms associated with depression caused by social isolation in adolescence, discusses the specific effects of adolescent social isolation on brain development, endocrine, neurotransmitters, and glial cells, and discusses its association with depression. |
| Key words: adolescence social isolation depression brain mechanism |
