Objective: To study the effects of fisetin on proliferation and collagen synthesis of immortalized rat hepatic stellate cell line：HSC-T6 cells . Methods: Cell proliferation was measured by crystal violet stain ing assay. Collagen synthesis was determined by 3H-proline incorporation. Results: Fisetin (6.25-50.00 μmol/L)markly inhibited PDGF-stim ulat ed proliferation and TGFβ1-stimulated collagen synthesis of HSC-T6 cells in a concentration-dependent manner. Conclusion: Fisetin could inhi bit actived hepatic lipocyte proliferation and collagen synthesis