| 摘要: |
| 目的:研究风湿性心脏病(RHD)心衰时心室肌中肌球蛋白轻链(VMLC)的变化与心脏重塑的关系。方法:采用Western blotting技术对13例RHD心衰患者及7例意外死亡者VMLC-1,VMLC-2含量进行定量分析。结果:RHD组VMLC-1,VMLC-2含量均显著低于正常对照组，以VMLC-2含量下降最明显，VMLC-1/VMLC-2比值在1∶0.95-1∶0.61。结论:RHD心衰发展过程中涉及了VMLC-1,VMLC-2蛋白水平的改变，这种改变可能对心功能的进行性恶化有直接影响。 |
| 关键词: 风湿性心脏病、心脏重塑、肌球蛋白轻链，心室型 |
| DOI： |
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| 基金项目: |
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| Alterations of myosin light chains in ventricular myocardium in patients with rheumatic heart disease |
| 史沁卫,朱泉芳,吴弘,郝家骅,张宝仁,朱家麟,郎希龙 |
| () |
| Abstract: |
| Objective: To study the changes of ven tricular myosin light chain (VMLC) and its relation with heart remodeling in rhe umatic heart disease (RHD). Methods: Using Western blotting hybrid izat ion assay, we detected VMLC-1，VMLC-2 in 13 patients with RHD and 7 cases of accidental deathes. Results: As compared with the normal group, the contents of VMLC-1 , VMLC-2 were all decreased significantly in RHD patients, especially the VMLC-2. The ratio of VMLC-1/VMLC-2 in RHD patients varied from 1∶0.95 to 1∶0.61. Conclusion: The values of VMLC-1, VMLC-2 and the ratio of VMLC-1/VMLC-2 are all changed during the development of heart remodeling i n RHD patients, suggesting that these changes may exert a direct effect on the progressive deterioration of heart function. |
| Key words: rheumatic heart disease heart remodeling myosin light chain, ventricle |
