Objective: To study correlation between CR1 genomic density polymorphism of erythrocytes and ability of erythrocytes adhering to tumour cells in variant population(normal people, patient with HBV infection, with hepatoc irrhosis and with hepatocarcinoma).Methods: Genomic determination of the CR1 density polymorphism (HH type, HL type, LL type) of erythrocytes was p erformed using polymerase chain reaction amplification and Hind Ⅲ retriction e nzyme digestion. Ability of erythrocytes adhering to tumour cells using tumour erythrocyte rosetest. Results: In different population,ability of HH type erythrocytes adhering to tumour cells was significantly higher than that of HL type erythrocytes. Ability of HL type erythrocytes adhering to tumour cells was significantly higher than that of LL type erythrocytes. In same CR1 genomic type population, ability of erythrocytes adhering to tumour cells in normal p eople significantly higher than that in patients with HBV infection and patients with hepatocirrhosis and patients with hepatocarcinoma. Conclusion: These results indicate that activity of erythrocytes adhering to tumour cells may be related to CR1 genomic density polymorphism type.