| 本文已被：浏览 1412次 下载 99次 |
|
| 超深低温和复苏对犬脑的影响 |
| 朱诚,袁国梁,蔡如珏,卢洪流,林兆奋,金焰,石学银,刘刚,江基尧,杨朋范 |
|
|
| () |
|
| 摘要: |
| 目的:研究超深低温对犬脑组织缺血的保护作用。方法:建立实验犬闭胸式体外循环,体内体外结合降温,并以海脉素置换行控制性放血,至红细胞比容降至5％左右。中心体温7-10℃维持低流量体外循环90 min。复温过程中回输自体血并予复苏。结果:7只犬中1只因技术因素死于术中,其余6只复苏后神经功能均恢复,但在2-4 h后均死于肺功能不全。病理检查示:脑、肝脏、肾脏正常;心脏轻度缺血性改变;肺水肿、肺泡出血明显。结论:超深低温下犬脑、肝、肾可耐受缺血90 min而无明确异常,但在复苏后维持肺功能困难。 |
| 关键词: 超深低温、脑缺血 |
| DOI： |
|
| 基金项目: |
|
| Effects of ultraprofound hypothermia and resuscitation on canine brain |
| 朱诚,袁国梁,蔡如珏,卢洪流,林兆奋,金焰,石学银,刘刚,江基尧,杨朋范 |
| () |
| Abstract: |
| Objective:To study the protecive effect of ultraprofound hypothermia on canine ischemic brain. Methods:Seven adult dogs underwent closed-chest extracorporeal circulation with both external and internal body cooling. As they were cooled, progressive hemodilution with Haemaccel was employed until the hematocrit decreased to 5%or so. Continuous circulation and a core temperature at 7-10℃ were maintained for 90 min. During rewarming, the animals were autotransfused and allowed to recover. Results:Of the 7 animals, one died intraoperatively due to technical factors related to closed-chest extracorporeal circulation, 6 surviving animals showed normal neurological functions, but died of dysfunction of lungs 2-4 h after resuscitation. Pathological examination revealed mild ischemic lesions of myopcardiac structure, pulmonary edema with microscopic alveolar hemorrhage and no histological abnormality of brain, liver or kidney. Conclusion:The canine brain, liver and kidney can tolerate ischemia for 90 min under ultraprofound hypothermia, despite the dysfunction of lungs after resuscitation. |
| Key words: ultraptofound hypothermia brain ischemia |
