| 摘要: |
| 目的:探讨妊娠高血压综合征(妊高征)患者脐血、羊水中降钙素基因相关肽(CGRP)含量的变化。方法:应用放射免疫测定法,观察26例正常妊娠妇女和32例妊高征患者脐血与羊水中CGRP含量的变化。结果:脐动脉血中CGRP含量,妊高征患者显著高于正常妊娠者(P＜0.05),且随着病情的加重逐渐增加,重度者显著高于轻度者(P＜0.05)；羊水中CGRP含量妊高征患者显著高于正常妊娠对照组(P＜0.05)；脐动脉血、羊水中CGRP含量的变化与新生儿1 min Apgar评分呈显著负相关(P＜0.01,P<0.05)。结论:脐动脉血、羊水中CGRP含量的变化可能与胎儿宫内缺氧有关。 |
| 关键词: 降钙素基因相关肽、妊娠并发症，高血压、胎血、羊水 |
| DOI： |
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| 基金项目: |
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| The changes of calcitonin gene related peptide levels in cord plasma and amniotic fluid of pregnancy induced hypertention patients |
| 王成海,戎霖,李娟 |
| () |
| Abstract: |
| Objective:To determine calcitonin gene related peptide (CGRP) levels in cord plasma and amniotic fluid of pregnancy induced hypertension (PIH) patients. Methods: CGRP levels in cord plasma and amniotic fluid of 26 normal pregnant women (NP group) were measured with radioimmunoassay (RIA).Results: Plasma CGRP levels in umbilical artery of PIH patients were significantly higher than that of NP women (P＜0.01),and it increased as the disease became worse, the severe increased markedly when compared with the mild (P＜0.05).CGRP levels in amniotic fluid of PIH patients were significantly higher than that of NP women(P＜0.05).There was a negative correlation between neonatal 1 min Apgar Scores after delivery and CGRP levels in umbilical artery(P＜0.01),as well as that in amniotic fluid(P＜0.05).Conclusion: The changes of CGRP levels in umbilical artery and amniotic fluid are correlated with intrauterine fetal distress |
| Key words: calcitonin gene related peptide pregnancy complications, hypertension fetal plasma amniotic fluid |
